The effects of captopril on myocardial ionic pump functions and sodium and calcium concentrations in mice with viral myocarditis

CHEN Jian-bin; et al

doi:10.13406/j.cnki.cyxb.2001.03.003

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The effects of captopril on myocardial ionic pump functions and sodium and calcium concentrations in mice with viral myocarditis

更新时间：2024-01-17

- The effects of captopril on myocardial ionic pump functions and sodium and calcium concentrations in mice with viral myocarditis
- Journal of Chongqing Medical University Issue 3, Pages: 231-234(2001)
- 作者机构：
  
  1. 重庆医科大学临床学院肾内科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2001.03.003
  CLC： R542.2
- Published：2001，
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[1]陈建斌,刘琼,饶邦复,常静.卡托普利对小鼠病毒性心肌炎心肌离子泵功能和钠钙代谢影响[J].重庆医科大学学报,2001(03):231-234.

CHEN Jian-bin, et al. The effects of captopril on myocardial ionic pump functions and sodium and calcium concentrations in mice with viral myocarditis. [J]. Journal of Chongqing Medical University (3):231-234(2001)
[1]陈建斌,刘琼,饶邦复,常静.卡托普利对小鼠病毒性心肌炎心肌离子泵功能和钠钙代谢影响[J].重庆医科大学学报,2001(03):231-234. DOI： 10.13406/j.cnki.cyxb.2001.03.003.

CHEN Jian-bin, et al. The effects of captopril on myocardial ionic pump functions and sodium and calcium concentrations in mice with viral myocarditis. [J]. Journal of Chongqing Medical University (3):231-234(2001) DOI： 10.13406/j.cnki.cyxb.2001.03.003.

摘要

目的：探讨病毒性心肌炎心肌离子泵功能及钠钙含量变化，并用卡托普利进行干预。方法：雄性Ｂａｌｂ／ｃ小鼠随机分为柯萨奇Ｂ３病毒（ＣＶＢ３）感染组（ＩＧ）、ＣＶＢ３感染加卡托普利治疗组（ＩＣＧ）及对照组（ＣＧ）。在不同病程分别测定心肌Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性，心肌钠钙含量及组织病理变化。结果：与ＣＧ比较，ＩＧ心肌Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性明显下降（Ｐ＜０．０１），钠钙含量显著升高（Ｐ＜０．０１），并早于心肌结构变化。ＩＣＧ上述各项指标较ＩＧ显著改善（Ｐ＜０．０５），心肌炎症、坏死也明显减轻（Ｐ＜０．０５）。结论：心肌离子泵功能下降，反常性Ｃａ２＋超载可能是造成病毒感染后心肌继发性损伤的重要因素；卡托普利能明显保护病毒性心肌炎心肌离子泵功能，降低心肌钠钙含量，改善心肌组织结构，促进预后。

Abstract

Objective:To explore the changes of myocardial ion ic pump functions and sodium and calcium concentrations in mice with viral myoca rditis

and to observe the intervention effects of captopril on them.Method s:The male Balb/c mice were randomly divided into three groups:infected c oxsackie B3 virus (CVB3)group (IG)

infected CVB3 and treated with captopr il group (ICG) and control group (CG). The activities of myocardial Na+

K+-A TPase and Ca2+-ATPase

the concentrations of myocardial sodium and cation a s well as the myocardial pathologic changes were investigated in different perio ds. Results:As compared to CG

the activities of myocardial Na+

K +-ATPase and Ca2+-ATPase of IG declined (P＜0.01)

the concentrations of myocardial sodium and calcium of IG increased(P＜0.01)

and these changes were observed prior to myocardial histologic abnormalities.All of these changes were obviously improved in ICG(P ＜0.05)

the myocytes necrosis and the myocytes inflammatory cells infiltration were reduced(P＜0.05). Conclusion： The inhibiti on of ionic pump functions and Ca2+ overload in Captopril can protect myo cardial ionic pump functions

reduce concentrations of myocardial sodium and ca lcium

ameliorate the myocardial histologic structure and improve the prognos is in viral myocarditis.

关键词

病毒性心肌炎离子泵钠钙卡托普利

Keywords

viral myocarditisIonic pumpSodiumcalciumCaptopril

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