Experimental study on repair or replacement of the bile duct with expanded polytetrafluoroethylene (ePTFE)

doi:10.13406/j.cnki.cyxb.2000.04.022

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Experimental study on repair or replacement of the bile duct with expanded polytetrafluoroethylene (ePTFE)

更新时间：2024-01-17

- Experimental study on repair or replacement of the bile duct with expanded polytetrafluoroethylene (ePTFE)
- Journal of Chongqing Medical University Issue 4, Pages: 393-395(2000)
- 作者机构：
  
  重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.04.022
  CLC： R318.14
- Published：2000，
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[1]任为,时德.膨体聚四氟乙烯修补与替代胆管的实验研究[J].重庆医科大学学报,2000(04):393-395+406.

Experimental study on repair or replacement of the bile duct with expanded polytetrafluoroethylene (ePTFE). [J]. Journal of Chongqing Medical University (4):393-395(2000)
[1]任为,时德.膨体聚四氟乙烯修补与替代胆管的实验研究[J].重庆医科大学学报,2000(04):393-395+406. DOI： 10.13406/j.cnki.cyxb.2000.04.022.

Experimental study on repair or replacement of the bile duct with expanded polytetrafluoroethylene (ePTFE). [J]. Journal of Chongqing Medical University (4):393-395(2000) DOI： 10.13406/j.cnki.cyxb.2000.04.022.

摘要

目的　为临床胆管缺损的处理探索新的选材。方法　通过切除部分胆管壁、整段切除胆总管的方式建立胆管损伤的犬模型，分别采用膨体聚四氟乙烯补片修补、管形材料替代胆管；观察动物在手术后的大体活动状况和造影了解胆管的通畅情况，并在不同的时间段切取胆管修复处的组织观察胆管组织的愈合过程及对材料的排异情况，两种修复方式对肝脏形态结构的影响。结果　采用补片修补组，胆管上皮能够覆盖材料表面，通畅率可达75%（9/12），胆汁引流通畅肝脏无损害；而整段替代胆管的通畅率只有40%（4/10），有不同程度的肝脏形态结构改变。结论　采用膨体聚四氟乙烯补片修补胆管缺损的结果比整段替代胆管满意（单侧Ｐ<0.05）。

Abstract

：Objective To explore the possibility of repair of the extensive bile duct injuries with expanded polytetrafluoroethylene (ePTFE). Methods A total of 24 local healthy hybrid dogs were employed to establish bile duct injury models by means of partial removal of bile duct

excision of a segmental duct. The bile duct defects were patched with ePTFE mesh

segmental loss replaced by ePTFE tube. The animals performance status and changes in the color of skin

sclera and stool were evaluated. Cholangiography was used to define the patency of bile duct with/without stricture and obstruction formation. Anastomotic tissue of bile ducts and liver tissues were taken at different time for microscopic and ultrastructural examination to determine foreign reactions to grafts

the healing process of bile duct and morphological changes in the liver. Results It was demonstrated that repair of the bile duct defects with ePTFE patch covered by epithelium had a high patency rate of 75%(9/12) and pathological damages were not found in the liver. The patency rate of segmental replacement of ducts was merely 40%(4/10)

to some extent

accompanying damages in the liver. Conclusion The study showed that repair of bile duct defects with ePTFE patch had better results than segmental replacement（unilaterally

Ｐ<0.05）.

关键词

膨体聚四氟乙烯胆管修复替代

Keywords

：Expanded polytetrafluoroethylene (ePTFE)Bile ductrepairReplacement

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