Clinical significance of P21ras protein expression in cervical squamous cell carcinoma

ZHOU Qin

doi:10.13406/j.cnki.cyxb.2000.04.019

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Clinical significance of P21ras protein expression in cervical squamous cell carcinoma

更新时间：2024-01-17

- Clinical significance of P21ras protein expression in cervical squamous cell carcinoma
- Journal of Chongqing Medical University Issue 4, Pages: 385-386(2000)
- 作者机构：
  
  重庆医科大学临床学院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.04.019
  CLC： R737.33
- Published：2000，
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[1]周勤.宫颈鳞癌中P21ras蛋白表达及临床意义[J].重庆医科大学学报,2000(04):385-386.

ZHOU Qin. Clinical significance of P21ras protein expression in cervical squamous cell carcinoma. [J]. Journal of Chongqing Medical University (4):385-386(2000)
[1]周勤.宫颈鳞癌中P21ras蛋白表达及临床意义[J].重庆医科大学学报,2000(04):385-386. DOI： 10.13406/j.cnki.cyxb.2000.04.019.

ZHOU Qin. Clinical significance of P21ras protein expression in cervical squamous cell carcinoma. [J]. Journal of Chongqing Medical University (4):385-386(2000) DOI： 10.13406/j.cnki.cyxb.2000.04.019.

摘要

目的　研究P21ras 蛋白表达与宫颈鳞癌发生发展的关系。方法　应用SP（Streptavidin--Peroxidase）免疫组化染色方法对10例正常宫颈组织、47例宫颈上皮内瘤样病变（CIN）和56例宫颈鳞癌组织的P21ras蛋白进行检测。结果　正常宫颈组织无P21ras 蛋白表达，CIN及宫颈鳞癌阳性表达率分别为36.17%、73.21%，三者间差异极为显著（Ｐ＜0.01）。CINⅠ、CINⅡ、CINⅢ表达率分别为16.67%、33.33%和55.56%，三者间差异显著（Ｐ＜0.05）。P21ras蛋白表达与宫颈鳞癌临床分期、组织学分级及淋巴结转移无关。结论　P21ras蛋白表达与宫颈鳞癌发生发展密切相关，并发生于癌变的早期阶段。

Abstract

：Objective To evaluate the relationship between P21ras protein and carcinogensis of cervical carcinoma. Methods Expression of P21ras in 10 normal cervical epithelia

47 cervical intraepithelial neoplasia and 56 cases of invasive squamous cervical carcinoma were determined by immunohistochemical method. Results There were no P21ras protein expression found in normal cervical epithelia

while the postive rates in CIN and carcinoma were 36.17%

73.21% respectively with significant difference (Ｐ<0.01). There was significant correlation between the grades of CIN and the P21ras protein positive rate (Ｐ<0.05). The expression of P21ras protein showed no signifficant difference between tumor grades and clinical stages of differentiation. Conclusion The results suggested that expression of P21ras protein might be useful in early detection of cervical carcinoma.

关键词

蛋白质P21宫颈上皮内瘤样病变宫颈鳞癌免疫组化

Keywords

P21ras Proteincervical intraepithelial neoplasiaInvasive squamous cell carcinomaImmunohistochemisitry

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Department of Gynecology and Obstetrics，the First Affiliated Hospital，Chongqing Medical University

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