The effect of serum soluble Fas and soluble Fas ligandin patients with hepatitis B

doi:10.13406/j.cnki.cyxb.2000.04.012

您当前的位置：

首页 >

文章列表页 >

The effect of serum soluble Fas and soluble Fas ligandin patients with hepatitis B

更新时间：2024-01-17

- The effect of serum soluble Fas and soluble Fas ligandin patients with hepatitis B
- Journal of Chongqing Medical University Issue 4, Pages: 365-367(2000)
- 作者机构：
  
  重庆医科大学病毒性肝炎研究所,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.04.012
  CLC： R512.6
- Published：2000，
扫描看全文
[1]秦波,张定凤,贾小平,任红.乙型肝炎患者血清可溶性Fas和可溶性Fas配体水平的研究[J].重庆医科大学学报,2000(04):365-367.

The effect of serum soluble Fas and soluble Fas ligandin patients with hepatitis B. [J]. Journal of Chongqing Medical University (4):365-367(2000)
[1]秦波,张定凤,贾小平,任红.乙型肝炎患者血清可溶性Fas和可溶性Fas配体水平的研究[J].重庆医科大学学报,2000(04):365-367. DOI： 10.13406/j.cnki.cyxb.2000.04.012.

The effect of serum soluble Fas and soluble Fas ligandin patients with hepatitis B. [J]. Journal of Chongqing Medical University (4):365-367(2000) DOI： 10.13406/j.cnki.cyxb.2000.04.012.

摘要

目的　研究可溶性Fas（sFas）和可溶性Fas配体（sFasL）在乙型肝炎发病中的意义。方法　用ELISA双抗体夹心法检测39例各种类型乙型肝炎患者血清sFas和sFasL含量及其与病变的关系，并以8例健康献血员血清作对照。结果　慢性肝炎（中～重型）血清中sFas含量较高，与其它各组比较有显著性差异（Ｐ<0.01）；重型肝炎血清中sFasL含量较高，与其它各组比较亦有显著性差异（Ｐ<0.01）。血清中sFasL含量较高的患者病情较重、病死率较高；相反，血清sFas含量较高的患者病情活动一般亦较明显，但绝大部分预后较好。结论　血清sFas和sFasL含量与乙型肝炎病情密切相关，二者可作为判断病情和估计预后的重要指标，它们在肝细胞凋亡引致肝损害的发生中起重要作用。

Abstract

To evaluate the effect of soluble Fas antigen (sFas) and soluble Fas ligand (sFasL) in the pathogenesis of hepatitis B. Methods Serum sFas and sFasL were detected by ELISA in 39 patients with hepatitis B. 8 healthy persons served as normal control. These levels were compared with the index of disease activity

including ALT levels

STB and PT levels. Results Serum sFas levels in moderate and severe degree CHB patients (CAH

5.38±3.50ng/ml) were significantly higher than those in other groups(Ｐ<0.01)

and serum sFasL levels in hepatic failure patients (FH

2.76±0.49ng/ml) were notably higher than those in other groups(Ｐ<0.01). Serum sFas and sFasL levels were correlated with disease activity

and most cases of the former had favourable prognosis. Conclusion The soluble form of Fas antigen in serum seemed to inhibit Fas-mediated apoptosis

and serum sFasL may reflect the severity of liver inflammation. They play important roles in hepatic apoptosis and necrosis

and may be responsible symbols for diagnosing pathogenetic condition and prognosis in hepatitis B.

关键词

病毒性肝炎乙型Fas/Fas配体可溶性细胞凋亡

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The effect of soybean isoflavones on induction of apoptosis on gastric cancer cell SGC-7901

Preliminary experimental study of the effects of vitreous cryopreservation with tetramethylpyrazine on schwann’s cell apoptosis and the expression of regulating gens

Related Author

ZHANG Junwen

et al

汤为学

LIU Jian-wen

et al

陈增刚

袁新

欧云生

Related Institution

Department of Gastroenterology, College of Clinical Medicine, Chongqing Medical University

重庆医科大学基础医学院病理生理教研室

Department of Orthopedics,the First Affiliated Hospital,Chongqing Medical University

⁰