Expression and significance of estrogen receptor in gastric carcinomas

doi:10.13406/j.cnki.cyxb.2000.04.009

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Expression and significance of estrogen receptor in gastric carcinomas

更新时间：2024-01-17

- Expression and significance of estrogen receptor in gastric carcinomas
- Journal of Chongqing Medical University Issue 4, Pages: 357-358(2000)
- 作者机构：
  
  重庆医科大学第二临床学院消化内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.04.009
  CLC： R735.2
- Published：2000，
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[1]张小雨,吴小翎.雌激素受体在胃癌细胞的表达和意义[J].重庆医科大学学报,2000(04):357-358.

Expression and significance of estrogen receptor in gastric carcinomas. [J]. Journal of Chongqing Medical University (4):357-358(2000)
[1]张小雨,吴小翎.雌激素受体在胃癌细胞的表达和意义[J].重庆医科大学学报,2000(04):357-358. DOI： 10.13406/j.cnki.cyxb.2000.04.009.

Expression and significance of estrogen receptor in gastric carcinomas. [J]. Journal of Chongqing Medical University (4):357-358(2000) DOI： 10.13406/j.cnki.cyxb.2000.04.009.

摘要

目的　检测雌激素受体（ER）在胃癌的表达及其与胃癌生物学行为的关系。方法　应用免疫组化S－P法。结果　ER在慢性浅表性胃炎、异型增生中表达均为阴性，在胃癌阳性率为40%，三组比较有显著性差异（Ｐ<0.05）。ER在进展期胃癌的阳性率显著高于早期胃癌（Ｐ<0.05）；胃癌有淋巴结转移组的阳性率显著高于无淋巴结转移组（Ｐ<0.05）。ER的表达在分化不良型胃癌高于分化型胃癌，但无统计学意义（Ｐ>0.05）。结论　ER 可作为胃癌的生物学标志， ER阳性的胃癌可能具有更强的浸润与转移能力。

Abstract

：Objective To study the relationship of expression ER with gastric mucosal carcinogenesis and behavior of gastric carcinoma. Methods S-P immunohistochemistry method. Results The study showed expression of ER was negative in chronic superficial gastritis and dysplasia.The positive rate of ER in gastric carcinomas was 40% . Statistically

the positive rates of ER in advanced gastric carcinomas were significantly higher than those in early gastric carcinomas（Ｐ<0.05）. The positive rates of ER in the group with lymph node metastasis were significantly higher than those in the group without lymph node metastasis (Ｐ<0.05). Conclusion ER might play important roles in the process of carcinogenesis of gastric mucosa ，and be used as useful markers for the assessment of biological behavior of gastric carcinoma .

关键词

雌激素受体癌前病变胃肿瘤免疫组化

Keywords

：Estrogen RecptorPrecancerous lesionStomach neoplasmsimmunohistochemistry

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