The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis

doi:10.13406/j.cnki.cyxb.2000.04.006

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The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis

更新时间：2024-01-17

- The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis
- Journal of Chongqing Medical University Issue 4, Pages: 350-351(2000)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科,重庆,400016
  2. 中山医科大学附属第一医院肝胆外科,广州,510089
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.04.006
  CLC： R735.7
- Published：2000，
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[1]孔宪炳,梁力建,黄洁夫.细胞凋亡在肝癌浸润转移过程中的状况[J].重庆医科大学学报,2000(04):350-351+354.

The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis. [J]. Journal of Chongqing Medical University (4):350-351(2000)
[1]孔宪炳,梁力建,黄洁夫.细胞凋亡在肝癌浸润转移过程中的状况[J].重庆医科大学学报,2000(04):350-351+354. DOI： 10.13406/j.cnki.cyxb.2000.04.006.

The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis. [J]. Journal of Chongqing Medical University (4):350-351(2000) DOI： 10.13406/j.cnki.cyxb.2000.04.006.

摘要

目的　研究肝细胞癌（HCC）凋亡在浸润转移过程中的重要性。方法　采用DNA 原位末端标记法（ISEL）、光镜、电镜，并结合计算机图象分析技术定量检测55例HCC的凋亡发生情况。结果　低分化HCC凋亡指数低于高分化HCC （Ｐ<0.05），浸润性和转移性HCC的凋亡指数分别低于非浸润性和无转移HCC（Ｐ<0.05和Ｐ<0.01）。结论　HCC凋亡指数与肿瘤的某些生物学特性有密切的联系，细胞凋亡的异常改变可能在HCC的浸润转移过程中起重要作用。

Abstract

Objective To explore the role of apoptosis in hepatocellular carcinoma(HCC) infiltration and intrahepatic metastasis. Methods Using the in situ DNA end-labeling

light microscopy

electron microscopy in combination with computer-imaging analytic technique

we tested quantitatively apoptotic cells in 55 HCC tissues. Results AI was significantly lower in poorly differentiated HCCs than well differentiated HCCs(Ｐ<0.05). Furthermore

HCCs with infiltration and intrahepatic metastasis had a significantly lower AI than those without infiltration and intrahepatic metastasis

respectively (Ｐ<0.05 and Ｐ<0.01). Conclusion AI has a close relation to some biological characteristics of HCC. The abnormal change in apoptosis may play an important role in the infiltration and intrahepatic metastasis of HCC.

关键词

肝细胞癌细胞凋亡浸润转移

Keywords

hepatocellular carcinomaapoptosisInfiltrationMetastasi?

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