The impact of open heart surgery with cardiapulmonary bypass under beating heart or rested heart on cTnI and MDA

doi:10.13406/j.cnki.cyxb.2000.03.027

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The impact of open heart surgery with cardiapulmonary bypass under beating heart or rested heart on cTnI and MDA

更新时间：2024-01-17

- The impact of open heart surgery with cardiapulmonary bypass under beating heart or rested heart on cTnI and MDA
- Journal of Chongqing Medical University Issue 3, Pages: 296-297(2000)
- 作者机构：
  
  重庆医科大学临床学院胸心外科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.027
  CLC： R654.2
- Published：2000，
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[1]李强,李朝先,向小勇.体外循环心脏停跳与不停跳行心内直视手术对血浆心肌肌钙蛋白Ⅰ和丙二醛的影响[J].重庆医科大学学报,2000(03):296-297.

The impact of open heart surgery with cardiapulmonary bypass under beating heart or rested heart on cTnI and MDA. [J]. Journal of Chongqing Medical University (3):296-297(2000)
[1]李强,李朝先,向小勇.体外循环心脏停跳与不停跳行心内直视手术对血浆心肌肌钙蛋白Ⅰ和丙二醛的影响[J].重庆医科大学学报,2000(03):296-297. DOI： 10.13406/j.cnki.cyxb.2000.03.027.

The impact of open heart surgery with cardiapulmonary bypass under beating heart or rested heart on cTnI and MDA. [J]. Journal of Chongqing Medical University (3):296-297(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.027.

摘要

目的通过心脏不停跳与停跳心内直视术对患者血浆心肌肌钙蛋白Ⅰ和丙二醛影响的对比研究，客观评价心脏不停跳心内直视术的心肌保护效果。方法随机将２７例二尖瓣病变患者分两组，测定术前、后心肌肌钙蛋白Ⅰ和丙二醛的变化。不停跳组１３例，二尖瓣替换在浅低温体外循环心脏不停跳下进行；停跳组１４例，二尖瓣替换在常规停跳方法下进行。结果不停跳组患者术后心肌肌钙蛋白Ⅰ和丙二醛显著低于停跳组（Ｐ＜０．０１）。结论浅低温体外循环心脏不停跳心内直视术的心肌保护效果好，对心肌损伤小，其主要原因是减轻了心肌缺血再灌注损伤。

Abstract

Objective To evaluate the myocardioprotective effect of beating heart surgery. Methods Twenty- seven patients with mitral lesions were randomly divided into two groups. Cardiac troponin Ⅰ(cTnl) and malonic dialdehyde(MDA) were investigaed preoperatively and postoperatively. 13cases in beating group with mitral valve replacement were performed on beating heart with mild hypothermia and CPB

and 14 cases in nonbeating group with mitral valve replacement were performed under conventional cardiac arrest. Results The postoperative cTnI and MDA in beating group were much lower than that in nonbeating group (P<0.01). Conclusion: The myocardioprotective effect of open heart surgery on beating heart is relatvely better than that of cardiac arrest

and the myocardial damage is lighter

because of less myocardial ischemia and reperfusion injury.

关键词

体外循环心肌肌钙蛋白Ⅰ丙二醛

Keywords

cardiopulmonary bypassCardiac troponin Ⅰmalonic dialdehyde

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