The protective role of ischemic preconditioning in Wistar rat heart

doi:10.13406/j.cnki.cyxb.2000.03.016

您当前的位置：

首页 >

文章列表页 >

The protective role of ischemic preconditioning in Wistar rat heart

更新时间：2024-01-17

- The protective role of ischemic preconditioning in Wistar rat heart
- Journal of Chongqing Medical University Issue 3, Pages: 268-269(2000)
- 作者机构：
  
  重庆医科大学临床学院心血管内科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.016
  CLC： R363
- Published：2000，
扫描看全文
[1]王悦喜,董莉,陈运贞,刘元生.心肌缺血预处理对心肌的保护作用[J].重庆医科大学学报,2000(03):268-269.

The protective role of ischemic preconditioning in Wistar rat heart. [J]. Journal of Chongqing Medical University (3):268-269(2000)
[1]王悦喜,董莉,陈运贞,刘元生.心肌缺血预处理对心肌的保护作用[J].重庆医科大学学报,2000(03):268-269. DOI： 10.13406/j.cnki.cyxb.2000.03.016.

The protective role of ischemic preconditioning in Wistar rat heart. [J]. Journal of Chongqing Medical University (3):268-269(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.016.

摘要

目的探讨心肌缺血预处理（ＩＰＣ）保护该心肌被以后较长时间缺血损伤的作用。方法给Ｗｉｓｔａｒ大鼠在９０ｍｉｎ缺血和１８０ｍｉｎ再灌注（Ｉ／Ｒ）前３次、每次５ｍｉｎ、间隔５ｍｉｎ再灌注的心肌缺血预处理；Ｉ／Ｒ前静脉注射Ｂｒｅ．、ＰＭＡ观察它们对心肌Ｉ／Ｒ损伤的影响作用。结果ＩＰＣ、ＰＭＡ可保护心肌被Ｉ／Ｒ的损伤；Ｂｒｅ．则可消除ＩＰＣ对心肌的保护作用。结论ＩＰＣ可保护心肌被长达９０ｍｉｎ．Ｉ／１８０ｍｉｎ．Ｒ损伤，其保护机制作者正在研究之中，可能与蛋白激酶Ｃ被激活有关。

Abstract

Objective To explore IPC(ischemic preconditioning) and PMA reduce the size of infarcts compared with control and breviscapini(Bre.). Methods and Results Anesthetized open-chest wistar rats underwent three 5- minute episodes of preconditioning ischemia in IPC group or after administration of Bre. in Bre.group; Control group had no episodes of ischemic preconditioning; PMA was injected 5 minutes before sustained occlusion; Afte- r 90 minutes of CAO and 3 hours of reperfusion

infarct size was significantly reduced in IPC rats’ compared with control group and Bre.+IPC groups

P<0.01. Conclusion The wistar rats IPC model was stable

TTC can obviously distinguish the AN(area of necrosis) from normal myocardium. The IPC、PMA protected the myocardium from sustained ischemia-reperfusion injury.Bre. blunted the protective role of IPC. PMA imitated the protective role of IPC. Their protective mechanism will be disscused in detail in next article.

关键词

预处理缺血心肌保护

Keywords

Myocardium infarctIschemic preconditioningmyocardial protection

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection

MYOCARDIAL PROTECTION IN THE HIGH RISK PATIENTS UNDERGOING VALAE REPLACEMENT

The role of heat shock、ischemic preconditioning in the delayed protection of ischemic preconditioning

Effect of mitral valve replacement between beating heart and arrested heart on calcitonin gene-related peptide and myocardial ultrastructure

Protective effects of polarizing cardioplegia with Na~+ channel inhibitor tetrodotoxin (TTX) on isolated rat hearts

Related Author

Wu Yanqing

Zeng Shengqiang

房秀生

刘元生

陈运贞

王悦喜

刘胡伟

WANG Bin

Related Institution

Department of Cardiology,the Second Affiliated Hospital of Nanchang University

重庆医科大学第一医院麻醉科

重庆医科大学基础医学院电镜室

重庆医科大学临床学院核医学科

Department of Thoracic and Cardiovascular , College of Clinical Medicine，Chongqing Medical University

⁰