Relationship between serum haptoglobin and insulin resistance in type 2 diabetes pedigrees

doi:10.13406/j.cnki.cyxb.2000.03.014

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Relationship between serum haptoglobin and insulin resistance in type 2 diabetes pedigrees

更新时间：2024-01-17

- Relationship between serum haptoglobin and insulin resistance in type 2 diabetes pedigrees
- Journal of Chongqing Medical University Issue 3, Pages: 262-264(2000)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科,400016
  2. 重庆医科大学临床学院血液科
  3. ,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.014
  CLC： R587.1
- Published：2000，
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[1]汪志红,张素华,邱鸿鑫,韩风,朱达英,任伟.2型糖尿病家系中血清结合珠蛋白水平和胰岛素抵抗[J].重庆医科大学学报,2000(03):262-264.

Relationship between serum haptoglobin and insulin resistance in type 2 diabetes pedigrees. [J]. Journal of Chongqing Medical University (3):262-264(2000)
[1]汪志红,张素华,邱鸿鑫,韩风,朱达英,任伟.2型糖尿病家系中血清结合珠蛋白水平和胰岛素抵抗[J].重庆医科大学学报,2000(03):262-264. DOI： 10.13406/j.cnki.cyxb.2000.03.014.

Relationship between serum haptoglobin and insulin resistance in type 2 diabetes pedigrees. [J]. Journal of Chongqing Medical University (3):262-264(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.014.

摘要

目的探讨血清结合珠蛋白（ＨＰ）水平与２型糖尿病家系胰岛素抵抗（ＩＲ）的关系。方法采用比色法检测健康人３０例，家族性２型糖尿病患者５０例及其家系中非ＤＭ一级亲属４４例的ＨＰ，同时测定空腹胰岛素（ＦＩＮＳ）、血脂及血浆脂蛋白。结果家族性２型糖尿病患者及一级亲属的ＨＰ、ＦＩＮＳ显著高于正常对照，并有脂代谢的紊乱；所有受试者的ＨＰ水平与胰岛素敏感指数呈负相关。结论本研究提示ＨＰ是ＩＲ的指标之一；ＨＰ水平升高可能是家族性２型糖尿病的一个遗传标志。

Abstract

Objective: We studied the relationship between haptoglobin (HP) and insulin resistance (IR) in type 2 diabetes pedigrees. Methods: The plasma concentrations of HP were determined in 30 healthy controls

50 familial type 2 diabetic patients and their 44 nondiabetic first-degree relatives by using colorimetry. Fasting plasma insulin (FINS)

plasma lipids and lipoproteins were measured simultaneously. Results: The level of HP and FINS were higher in both diabetic patients and their nondiabetic first-degree relatives than those in the healthy subjects. Besides

the former two groups were found to have dyslipidemia. HP was inversely correlated with the insulin sensitivity index in all subjects. Conclusion:The study indicated that HP may be closely associated with IR. The increased level of HP may be one of the hereditary markers of familial type 2 diabetes.

关键词

结合珠蛋白胰岛素抵抗2型糖尿病

Keywords

Haptoglobininsulin resistancetype 2 diabetes

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Related Institution

Department of Endocrinology

Department of Gastrointestinal Surgery，The First Affiliated Hospital of Chongqing Medical University

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Department of Laboratory Medicine，The First Affiliated Hospital of Shandong First Medical University/Shandong Provincial Qianfoshan Hospital，Shandong Provincial Medicine and Health Key Laboratory of Clinical Laboratory Diagnostics

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