Studies on synthesis of antidiabetic drug troglitazone

doi:10.13406/j.cnki.cyxb.2000.03.012

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Studies on synthesis of antidiabetic drug troglitazone

更新时间：2024-01-17

- Studies on synthesis of antidiabetic drug troglitazone
- Journal of Chongqing Medical University Issue 3, Pages: 256-258(2000)
- 作者机构：
  
  重庆医科大学药物化学与生物材料研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.012
  CLC： R914.5
- Published：2000，
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[1]余瑜,郭亚飞,吴骏,严燊和.抗2型糖尿病新药曲格列酮的合成研究[J].重庆医科大学学报,2000(03):256-258.

Studies on synthesis of antidiabetic drug troglitazone. [J]. Journal of Chongqing Medical University (3):256-258(2000)
[1]余瑜,郭亚飞,吴骏,严燊和.抗2型糖尿病新药曲格列酮的合成研究[J].重庆医科大学学报,2000(03):256-258. DOI： 10.13406/j.cnki.cyxb.2000.03.012.

Studies on synthesis of antidiabetic drug troglitazone. [J]. Journal of Chongqing Medical University (3):256-258(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.012.

摘要

目的研究曲格列酮的合成路线。方法为避免选择性醚化反应，将前两步（还原和选择性醚化）反应，重新设计和调整为三步反应，即酯化、醚化和还原反应。结果每步反应专属性较强。有二个新的化合物（Ⅱ）和（Ⅲ）生成；整个反应革除了用柱色谱分离而直接得到产物。结论酚醚化反应收率为９８％，比文献报道提高了１０％以上。总收率约为１７％，并有工业化生产的可能。

Abstract

Objective This paper reported the studies on synthesis of troglitazone. Methods The three steps (esterification

etherization and reduction) were changed for the first two steps (reduction and selected etherization). Results The two new compounds Ⅱ and Ⅲ were obtained

and these were obtained without column chromatography in all reactions. Conclusion The experimental results showed that the yield(98%) of etherization was 10% more than that reported in the literature. The total yield is about 17%.

关键词

曲格列酮合成2型糖尿病非胰岛素依赖性糖尿病

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