Expression of p53 protein, c-erbB-2 and PCNA in rhabdomyosarcoma

doi:10.13406/j.cnki.cyxb.2000.03.009

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Expression of p53 protein, c-erbB-2 and PCNA in rhabdomyosarcoma

更新时间：2024-01-17

- Expression of p53 protein, c-erbB-2 and PCNA in rhabdomyosarcoma
- Journal of Chongqing Medical University Issue 3, Pages: 247-248(2000)
- 作者机构：
  
  重庆医科大学基础医学院病理学教研室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.009
  CLC： R738.7
- Published：2000，
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[1]彭真年,米粲,李圆圆.p53、c-erbB-2和PCNA在横纹肌肉瘤中的表达[J].重庆医科大学学报,2000(03):247-248+252.

Expression of p53 protein, c-erbB-2 and PCNA in rhabdomyosarcoma. [J]. Journal of Chongqing Medical University (3):247-248(2000)
[1]彭真年,米粲,李圆圆.p53、c-erbB-2和PCNA在横纹肌肉瘤中的表达[J].重庆医科大学学报,2000(03):247-248+252. DOI： 10.13406/j.cnki.cyxb.2000.03.009.

Expression of p53 protein, c-erbB-2 and PCNA in rhabdomyosarcoma. [J]. Journal of Chongqing Medical University (3):247-248(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.009.

摘要

目的探讨横纹肌肉瘤癌基因蛋白和增殖细胞核抗原（ＰＣＮＡ）的表达与横纹肌肉瘤的类型、分化程度和复发、转移的关系。方法应用免疫组化ＡＢＣ法检测２６例横纹肌肉瘤ｐ５３、ｃ－ｅｒｂＢ－２和ＰＣＮＡ的表达。结果ｐ５３、ｃ－ｅｒｂＢ－２和ＰＣＮＡ的阳性率分别为７６．９％，１９％和１００％。ｐ５３阳性表达与横纹肌肉瘤的类型无关（Ｐ＞０．０５），而与横纹肌肉瘤的分化程度和复发、转移有关（Ｐ＜０．０５）。ｃ－ｅｒｂＢ－２的阳性率低，其阳性表达与横纹肌肉瘤的类型、分化程度及复发、转移均无相关性。ＰＣＮＡ的表达程度与横纹肌肉瘤的复发、转移有关。结论ｐ５３和ＰＣＮＡ能较好地反映横纹肌肉瘤的恶性程度。可作为评估横纹肌肉瘤复发、转移的指标之一。

Abstract

Objective To explore the relationship between the expression of oncoprotein

proliferating cell nuclear antigen (PCNA)

histological type

degree of differentiation

recurrence and metastasis in rhabdomyosarcoma (RMS). Methods Immunohistochemical ABC method was used to study the expression of p53 protein

c-erbB-2 and PCNA in 26 cases of RMS. Results The positive rates of p53

c-erbB-2 and PCNA expression were 76.9%

19.2% and 100% respectively. The positive expression of p53 was not related to RMS histological type (P>0.05)

but to the degree of RMS differentiation

recurrence and metastasis(P<0.05). The positive rate of c-erbB-2 expression was not clearly observed. and not related to RMS histological type

degree of differentiation

recurrence and metastasis. The intensity of PCNA expression was related to recurrence and metastasis. Conclusion The results suggest that p53 and PCNA could reflect the malignant degree of RMS to a certain extent. The expression of p53 and PCNA may be an index to appraise the recurrence and metastasis of RMS.

关键词

横纹肌肉瘤p53C-erbB-2增殖细胞核抗原免疫组化

Keywords

rhabdomyosarcomap53C-erbB-2proliferating cell nuclear antigenimmunohistochemistry

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