Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats

doi:10.13406/j.cnki.cyxb.2000.03.007

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Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats

更新时间：2024-01-17

- Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats
- Journal of Chongqing Medical University Issue 3, Pages: 242-244(2000)
- 作者机构：
  
  重庆医科大学临床学院心血管内科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.007
  CLC： R544.1
- Published：2000，
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[1]周建中,雷寒,李法琦,陈运贞.依那普利、福辛普利逆转高血压心室重塑的实验研究[J].重庆医科大学学报,2000(03):242-244.

Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats. [J]. Journal of Chongqing Medical University (3):242-244(2000)
[1]周建中,雷寒,李法琦,陈运贞.依那普利、福辛普利逆转高血压心室重塑的实验研究[J].重庆医科大学学报,2000(03):242-244. DOI： 10.13406/j.cnki.cyxb.2000.03.007.

Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats. [J]. Journal of Chongqing Medical University (3):242-244(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.007.

摘要

目的观察血管紧张素转换酶抑制剂Ｅｎａｌａｐｒｉｌ和Ｆｏｓｉｎｏｐｒｉｌ对ＳＨＲ心脏血管重塑逆转作用。方法将１０月龄１８只ＳＨＲ（ＳＨＲ１０）随机分为Ｅｎａｌａｐｒｉｌ（ＳＨＲＥ）、Ｆｏｓｉｎｏｐｒｉｌ（ＳＨＲＦ）和生理盐水（ＳＨＲＣ）三组，给药剂量为１０ｍｇ／ｋｇ／ｄ腹腔内注射连续８周。测定血压、心室重量指数，用偏振光镜观察心脏、血管结构改变。图象分析计算心肌间质胶原面积、含量。结果两药物均使心室肥厚不同程度消退，部分逆转心肌、间质、血管的结构改变，心肌间质胶原容积分数（ＣＶＦ）降低，而且Ｆｏｓｉｎｏｐｒｉｌ降低ＬＶＷ／ＢＷ比Ｅｎａｌａｐｒｉｌ更好（Ｐ＜０．０５）。结论福辛普利、依那普利可逆转ＳＨＲ心肌、间质、血管重构，改善心肌僵硬度。

Abstract

Objective This study observed the effects of angiotension converting enzyme inhibitor Enalapril & Fosinopril on reversion of ventricular remodeling in spontaneously hypertensive rats. Methods 18 SHRs were divided into three groups at random. enalapril

fosinopril or saline (10mg/kg/d) was injected intraperitoneally into rats of each group rat respectively. Systolic blood pressure and ventricular weight index (LVW/BW

RVW/BW) were measured. Picrosirus Red staining was used to determine cardiovascular morphology of collagen with polarization microscope and image analyzer system (IAS) to estimate interstitial collagen volume fraction (CVF). Results The effect of enalapril and fosinopril was similar in decreasing SBP

RVW/BW and CVF. Fosinopril was better than enalapril in decreasing LVW/BW (P<0.05). Conclusion Enalapril and fosinolpril lead to reversing the ventricular remodeling and improving cardiomuscular stiffness.

关键词

自发性高血压大鼠心室重构福辛普利依那普利胶原

Keywords

Spontaneously hypertensive ratsventricular remodelingFosinoprilenalaprilCollagen

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