Relationship between PCNA and p53、c-erbB-2 oncogene protein in malignant and premalignant lesions in breast

doi:10.13406/j.cnki.cyxb.2000.03.005

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Relationship between PCNA and p53、c-erbB-2 oncogene protein in malignant and premalignant lesions in breast

更新时间：2024-01-17

- Relationship between PCNA and p53、c-erbB-2 oncogene protein in malignant and premalignant lesions in breast
- Journal of Chongqing Medical University Issue 3, Pages: 236-238(2000)
- 作者机构：
  
  重庆医科大学临床学院普外科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.005
  CLC： R737.9
- Published：2000，
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[1]刘胜春,吴凯南,厉红元.PCNA和p53、c-erbB-2癌基因蛋白在乳腺癌前病变及癌变过程中的相关性[J].重庆医科大学学报,2000(03):236-238+241.

Relationship between PCNA and p53、c-erbB-2 oncogene protein in malignant and premalignant lesions in breast. [J]. Journal of Chongqing Medical University (3):236-238(2000)
[1]刘胜春,吴凯南,厉红元.PCNA和p53、c-erbB-2癌基因蛋白在乳腺癌前病变及癌变过程中的相关性[J].重庆医科大学学报,2000(03):236-238+241. DOI： 10.13406/j.cnki.cyxb.2000.03.005.

Relationship between PCNA and p53、c-erbB-2 oncogene protein in malignant and premalignant lesions in breast. [J]. Journal of Chongqing Medical University (3):236-238(2000) DOI： 10.13406/j.cnki.cyxb.2000.03.005.

摘要

目的研究乳腺非典型增生及癌变过程中ＰＣＮＡ及癌基因蛋白ｐ５３、ｃ－ｅｒｂＢ－２的变化规律，并探讨在此过程中细胞增殖活性与ｐ５３、ｃ－ｅｒｂＢ－２癌基因蛋白表达的关系。方法应用免疫组化法分析了８６例良恶性乳腺组织中的ＰＣＮＡ，癌基因蛋白ｐ５３、ｃ－ｅｒｂＢ－２表达及其相互关系。结果ＰＣＮＡ、ｐ５３、ｃ－ｅｒｂＢ－２的表达随非典型增生程度的增加而增多。ｐ５３、ｃ－ｅｒｂＢ－２阳性表达病例ＰＣＮＣＮ－ＬＩ明显高子阴性病例（ｔ＝２．９０４０，Ｐ＜０．０１；ｔ＝３．２３３３，Ｐ＜０．０１）。结论ＰＣＮＡ、ｐ５３、ｃ－ｅｒｂＢ－２可反映乳腺癌前病变的恶变倾向，并对癌前病变的临床处理和随访有指导作用；细胞增殖活性与ｒ５３、ｃ－ｅｒｂＢ－２基因激活，蛋白产物聚积有密切联系。

Abstract

Objective To evaluate cell proliferating activity and expression of P53. c-erbB-2 oncogene protein in breast carcinoma and premalignant lesions in breast and to investigate the relationship of proliferating cell nuclear Aantigen (PCNA) with p53. c-erbB-2 oncogene protein. Methods Immunohistoch emical reaction of PCNA and p53. c-erbB-2 oncogene protein was evaluated in 61 benign lesion and 25 malignant breast paraffinembeded specimens. The relationships of PCNA-Labeling Index (PCNA-LI) and p53 、c-erbB-2 oncogene protein with hyperplasia condition and PCNA-LI with p53、c-erbB-2 oncogene protein were analyzed. Results The expression of PCNA and p53. c-erbB-2 oncogene protein significantly increased with the increased breast atypical hyperplasia condition. PCNA-LI of positive expression for p53 or c-erbB-2 was significantly higher than that of negative respectively (t =2.9040

P <0.01

t =3.2333

P<0. 01). Conclusion The expression of PCNA and p53. c-erbB-2 oncogene protein may indicate the risk of breast premalignant for carcinoma and direct clinical treatment and follow-up for premalignant

and in the meantime the cell proliferating activity had close relation to p53. c-erbB-2 oncogene activation and protein accumulation.

关键词

乳腺癌前病变乳腺癌癌基因表达增殖细胞核抗原

Keywords

Breast premalignant lesionbreast carcinomaProliferating cell nuclear antigenOncogene protein

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