The relationship between angiotensin-converting enzyme gene   polymorphism and essential hypertension in Chongqing

doi:10.13406/j.cnki.cyxb.2000.02.028

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The relationship between angiotensin-converting enzyme gene polymorphism and essential hypertension in Chongqing

更新时间：2024-01-17

- The relationship between angiotensin-converting enzyme gene polymorphism and essential hypertension in Chongqing
- Journal of Chongqing Medical University Issue 2, Pages: 184-185(2000)
- 作者机构：
  
  1. 重庆医科大学临床学院中心实验室,400016
  2. 重庆医科大学临床学院心内科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.028
  CLC： R544.1
- Published：2000，
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[1]柳青,王曦,雷寒.缺失型血管紧张素转换酶基因与重庆地区原发性高血压的关系[J].重庆医科大学学报,2000(02):184-185+207.

The relationship between angiotensin-converting enzyme gene polymorphism and essential hypertension in Chongqing. [J]. Journal of Chongqing Medical University (2):184-185(2000)
[1]柳青,王曦,雷寒.缺失型血管紧张素转换酶基因与重庆地区原发性高血压的关系[J].重庆医科大学学报,2000(02):184-185+207. DOI： 10.13406/j.cnki.cyxb.2000.02.028.

The relationship between angiotensin-converting enzyme gene polymorphism and essential hypertension in Chongqing. [J]. Journal of Chongqing Medical University (2):184-185(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.028.

摘要

目的 :为探讨重庆地区原发性高血压与血管紧张素转换酶基因（ACE）插入 /缺失（I/D）多态性的关系。方法 :采用多聚酶链反应直接扩增ACE基因第 16内含子

对 114例正常人和 75例原发性高血压患者进行分析

得到三种基因型 :纯合插入型（II型）、纯合缺失型（DD型）、杂合型（ID型）。结果 :原发性高血压患者ACE基因的DD型频率明显高于正常人（χ2=13.75

P <0 .0 0 5 ）

D等位基因频率也明显高于正常人（χ2 =14.3 ;P <0 .0 0 5 ）

统计学分析差异有显著性意义。结论 :ACE基因的缺失型（DD型）可能与重庆地区原发性高血压的发病有关系

Abstract

Objective :To study the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with essential hypertension in Chongqing. Methods:We use polymerase chain reaction (PCR) method to amplify sixteenth intron of ACE gene to analyse 114 healthy controls and 75 patients with essential hypertension. Polymorphism was characterized by three genotypes: homozygous alleles DD

and heterozygous alleles ID. Results:The frequency of homozygous alleles DD and the frequency of deletion alleles were significantly higher in the essential hypertension group than in the healthy controls (P<0.005). Conclusion:The results indicate that a deletion polymorphism of ACE gene is associated with essential hypertension in Chongqing.

关键词

血管紧张素转换酶基因多态性原发性高血压

Keywords

Angiotensin converting enzyme (ACE)gene polymorphismEssential hypertension

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