Significance  of  thyroid hormone change in  patients with  chronic renal  insufficiency

doi:10.13406/j.cnki.cyxb.2000.02.024

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Significance of thyroid hormone change in patients with chronic renal insufficiency

更新时间：2024-01-17

- Significance of thyroid hormone change in patients with chronic renal insufficiency
- Journal of Chongqing Medical University Issue 2, Pages: 174-176(2000)
- 作者机构：
  
  重庆医科大学第二临床学院肾内科,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.024
  CLC： R692.5
- Published：2000，
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[1]张玲,文俐,李青,雷建容.慢性肾功不全患者甲状腺激素的改变及意义[J].重庆医科大学学报,2000(02):174-176.

Significance of thyroid hormone change in patients with chronic renal insufficiency. [J]. Journal of Chongqing Medical University (2):174-176(2000)
[1]张玲,文俐,李青,雷建容.慢性肾功不全患者甲状腺激素的改变及意义[J].重庆医科大学学报,2000(02):174-176. DOI： 10.13406/j.cnki.cyxb.2000.02.024.

Significance of thyroid hormone change in patients with chronic renal insufficiency. [J]. Journal of Chongqing Medical University (2):174-176(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.024.

摘要

目的 :观察慢性肾功能不全各期患者血清甲状腺激素的变化

探讨肾脏受损对其影响及临床意义。方法 :5 1例患者被分为代偿期、失代偿期和衰竭期三组。采用放射免疫法检测血清FT3、FT4 、TT3、TT4 、rT3、TSH。结果 :血清FT3、FT4 、TT3、TT4 降低程度随肾功能损害的加重而明显。肾功能失代偿期Ccr与TT3 呈显著正相关

Scr与TT3 呈显著负相关 ;衰竭期Ccr与TT3、FT3、TT4 呈显著正相关

Scr与TT3、FT3、TT4 呈显著负相关。结论 :血清FT3、TT3、TT4 的变化与肾脏受损害程度密切相关

可以作为评估肾脏病变的严重程度、功能代偿状态及预后的客观指标

Abstract

Objective: To investigate the correlation between renal damage and thyroid hormone in patients with chronic renal insufficiency. Methods: 51 cases were divided into three groups---compensation

decompensation and failure. The serum FT 3、FT 4、TT 3、TT 4、rT 3 and TSH levels in all patients were detected by RIA method. Results: The levels of FT 3、FT 4、TT 3、TT 4 were significantly low in patients with serious impairment of renal function (P<0.001). There was a positive correlation between Ccr and TT 3 (r=0.722

P<0.001)

a negative correlation between Scr and TT 3(r=-0.842

P<0.001) in decompensatied group. A positive correlation between Ccr and TT 3、FT 3、TT 4 and anegative correlation between Scr and TT 3、FT 3、TT 4 in group Ⅲ were found. Conclusion: There is a close relationship between levels of serum FT 3、TT 3、TT 4 and renal damage. Change of thyroid hormone might be a marker for evaluation in clinical situation

functional compensation and prognosis of patients with renal insufficiency.

关键词

慢性肾功能不全甲状腺激素

Keywords

Chronic renal insufficiencythyroid hormone

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Department of Endocrinology and Metabolism，The Affiliated Hospital of Kunming University of Science and Technology/The First People’s Hospital of Yunnan Province

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