Surveillance of bacterial resistance of clinical isolates to   10 antimicrobial agents

doi:10.13406/j.cnki.cyxb.2000.02.014

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Surveillance of bacterial resistance of clinical isolates to 10 antimicrobial agents

更新时间：2024-01-17

- Surveillance of bacterial resistance of clinical isolates to 10 antimicrobial agents
- Journal of Chongqing Medical University Issue 2, Pages: 148-150(2000)
- 作者机构：
  
  重庆医科大学临床学院传染科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.014
  CLC： R446.5
- Published：2000，
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[1]肖永红,李崇智,郑行萍,刘鸿渝,陈海,王其南.常见细菌对10种抗菌药物耐药性监测[J].重庆医科大学学报,2000(02):148-150.

Surveillance of bacterial resistance of clinical isolates to 10 antimicrobial agents. [J]. Journal of Chongqing Medical University (2):148-150(2000)
[1]肖永红,李崇智,郑行萍,刘鸿渝,陈海,王其南.常见细菌对10种抗菌药物耐药性监测[J].重庆医科大学学报,2000(02):148-150. DOI： 10.13406/j.cnki.cyxb.2000.02.014.

Surveillance of bacterial resistance of clinical isolates to 10 antimicrobial agents. [J]. Journal of Chongqing Medical University (2):148-150(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.014.

摘要

目的 :监测我院 1994～ 1995年临床分离菌耐药性 ;方法 :采用试管双倍稀释法测定 10种抗菌药物最低抑菌浓度 ;结果 :共测细菌 6 89株

其中革兰阳性菌 2 5 2株

革兰氏阴性菌 437株

结果 :表明各种细菌对氟喹诺酮类耐药性明显增加

其中大肠杆菌耐药率 >40 % ;头孢噻肟与头孢哌酮仍具较强抗菌活性

但耐头孢哌酮绿脓杆菌明显上升达 34% ;阿米卡星对肠杆菌科细菌仍有较强抗菌活性

但对庆大霉素耐药率较高 ;各种细菌对氨苄西林耐药率 >70 %

该药不再适合临床应用 ;痢疾杆菌、伤寒杆菌对各种药物仍有较高敏感性

耐药率 <16 % ;结论 :细菌对氟喹诺酮类耐药性迅速增加

对第三代头孢菌素与阿米卡星敏感性较高

Abstract

Objective:To investigate the antibiotic resistance of bacteria clinically isolated from 1994 to 1995 in our hospital. Methods:Bacterial susceptibility to 10 antimicrobial agents was examined with double dilution test. Results:689 clinical bacterial strains isolated in our hospital from 1994 to 1995 were collected in the study

which included 252 Gram positive and 437 Gram negative strains. Results:showed that bacterial resistance to fluoroqinolones increased obviously. The resistant rate of Escherichia coli was >40%. Cefotaxime and cefoperazone still kept potent antibacterial activity

but resistant rate of Psuedomonas aeroginosa to cefoperazone increased to 34%. Amikacin remained a powerful agent against enterobacteriaceae

resistant rate to gentamycin was higher. Most strains were resistant to ampicillin with an increased resistant rate of over 70%. Shigella spp and Samonella typhi were still susceptible to each antibiotics

and the resistant rates were lower than 16%. Conclusion:Bacterial resistance to fluoroquinolones increased obviously

while the third generation cephalosporins and amikacin keep higher antibacterial activity.

关键词

细菌耐药性监测

Keywords

Bacterialantibiotic resistancesurveillance

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