The change of plasma D-dimer levels and its relation to  hemorrheology and blood lipids in patients with NIDDM

doi:10.13406/j.cnki.cyxb.2000.02.011

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The change of plasma D-dimer levels and its relation to hemorrheology and blood lipids in patients with NIDDM

更新时间：2024-01-17

- The change of plasma D-dimer levels and its relation to hemorrheology and blood lipids in patients with NIDDM
- Journal of Chongqing Medical University Issue 2, Pages: 140-141(2000)
- 作者机构：
  
  1. 重庆医科大学临床学院检验科,400016
  2. 重庆医科大学临床学院内分泌科,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.011
  CLC： R587.1
- Published：2000，
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[1]祝继华,邱大为,肖勤,汪志红.2型糖尿病患者血浆D-二聚体的变化与血液流变和血脂的关系[J].重庆医科大学学报,2000(02):140-141+150.

The change of plasma D-dimer levels and its relation to hemorrheology and blood lipids in patients with NIDDM. [J]. Journal of Chongqing Medical University (2):140-141(2000)
[1]祝继华,邱大为,肖勤,汪志红.2型糖尿病患者血浆D-二聚体的变化与血液流变和血脂的关系[J].重庆医科大学学报,2000(02):140-141+150. DOI： 10.13406/j.cnki.cyxb.2000.02.011.

The change of plasma D-dimer levels and its relation to hemorrheology and blood lipids in patients with NIDDM. [J]. Journal of Chongqing Medical University (2):140-141(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.011.

摘要

目的 :为探讨 2型糖尿病（DM ）患者凝血及纤溶活性与血液流变学的关系

方法 :采用ELISHA法测定了 6 5例 2型DM患者和 30名正常对照的血浆D -二聚体水平

同时测定血粘度和血脂。结果 :显示 2型DM患者血浆D -二聚体

血粘度

总胆固醇和甘油三脂水平显著高于正常对照组（P <0 .0 1）

伴有视网膜病变 2型DM组的血浆D -二聚体

全血粘度

血浆粘度

红细胞聚积指数和变形指数均高于无视网膜病变组（P <0 .0 1） ;血浆D -二聚体水平与空腹血糖

全血粘度低切率和血浆粘度呈正相关（P <0 .0 1）。结论 :提示 2型DM患者存在血凝和纤溶活性增高

并与血液流变学改变密切相关 ;血浆D -二聚体是监测 2型DM血凝和纤溶状态的良好指标

Abstract

Objective: In order to investingate the coagulability and fibrinolysis and its relation to hemorrheological alterations in the NIDDM patients. Methods: The plasma concentrations of D-dimer in 65 NIDDM patients and 30 healthy subjects were determined by using a sandwich ELISA; blood viscosity and serum lipids were measured simultaneously. Results: The results showed that the levels of D-dimer

blood viscosity

cholesterol and triglyceride in NIDDM patients were significantly higher than those in healthy subjects (P<0.01) .There was significantly higher level of plasma D-dimer and indexes of hemorrheology in diabetics with retinopathy than in diabetics without retinopathy(P<0.01). The level of D-dimer was correlated positively with low shear of blood viscosity

plasma viscosity and fasting blood glucose in NIDDM patients (P<0.01) .Conclusion: The above findings indicate that in NIDDM patients

there are increases in coagulability and fibrinolysis

which are closely related to alterations of hemorrheology.Plasma D-dimer is useful for monitoring coagulation and fibinolysis in NIDDM patients .

关键词

糖尿病D-二聚体血液流变学

Keywords

diabetesD-dimerHemorrheology

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