The median-effect principle was used in the interaction between   DDP,VP-16 on human lung cancer cell line(PAa)

doi:10.13406/j.cnki.cyxb.2000.02.003

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The median-effect principle was used in the interaction between DDP,VP-16 on human lung cancer cell line(PAa)

更新时间：2024-01-17

- The median-effect principle was used in the interaction between DDP,VP-16 on human lung cancer cell line(PAa)
- Journal of Chongqing Medical University Issue 2, Pages: 118-120(2000)
- 作者机构：
  
  重庆医科大学基础医学院病理生理教研室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.003
  CLC： R734.2
- Published：2000，
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[1]沈宜,汤为学,段红,唐俐.中效原理在顺铂、足叶乙甙对人肺癌细胞株(PAa)相互作用中的应用[J].重庆医科大学学报,2000(02):118-120.

The median-effect principle was used in the interaction between DDP,VP-16 on human lung cancer cell line(PAa). [J]. Journal of Chongqing Medical University (2):118-120(2000)
[1]沈宜,汤为学,段红,唐俐.中效原理在顺铂、足叶乙甙对人肺癌细胞株(PAa)相互作用中的应用[J].重庆医科大学学报,2000(02):118-120. DOI： 10.13406/j.cnki.cyxb.2000.02.003.

The median-effect principle was used in the interaction between DDP,VP-16 on human lung cancer cell line(PAa). [J]. Journal of Chongqing Medical University (2):118-120(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.003.

摘要

目的 :利用中效原理观察顺铂、足叶乙甙配伍在体外对人肺癌细胞株（PAa）的相互作用

判断联合用药的效果。方法 :采用MTT法利用中效原理判断联合用药的效果。结果 :两种药物单独应用时随药物剂量增加

其效应也增加

两种药物合用时产生协同作用

两种药物合用时的浓度比例及给药时间次序不同均会影响效应大小。结论 :上述两种药物合用产生协同作用

合用时的效应大小与两种药物浓度比例及给时间次序有关

Abstract

Objective: The median-effect principle was used to evaluate the killing effects of DDP and VP-16 on human lung cancer cell line(PAa).Methods:The median-effect principle was used.Results:Killing effects of the individual drugs were enhanced as drag concentration increased. We also observed that the interacter of drugs was synergistic . The ratio of drug concentrations and the sequence of adminiatration were factors to influence the killing effects. Conclusion:The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.

关键词

顺铂足叶乙甙联合应用中效原理合用指数抗癌药物敏感性试验

Keywords

cisplatinEtoposideAnticancer grug combinationMedian-effect principleCombination index(CI)Anticancer drug sensitivity test

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