A study on the relationship between the infection of human   cytomegalovirus(HCMV) and the variation of  kinetochore

doi:10.13406/j.cnki.cyxb.2000.02.001

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A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore

更新时间：2024-01-17

- A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore
- Journal of Chongqing Medical University Issue 2, Pages: 113-114(2000)
- 作者机构：
  
  重庆医科大学计划生育系遗传优生教研室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.02.001
  CLC： R373
- Published：2000，
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[1]翁亚光,王应雄,刘学庆,何俊琳,陈雪梅.人巨细胞病毒感染与染色体着丝粒点变异关系研究[J].重庆医科大学学报,2000(02):113-114.

A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore. [J]. Journal of Chongqing Medical University (2):113-114(2000)
[1]翁亚光,王应雄,刘学庆,何俊琳,陈雪梅.人巨细胞病毒感染与染色体着丝粒点变异关系研究[J].重庆医科大学学报,2000(02):113-114. DOI： 10.13406/j.cnki.cyxb.2000.02.001.

A study on the relationship between the infection of human cytomegalovirus(HCMV) and the variation of kinetochore. [J]. Journal of Chongqing Medical University (2):113-114(2000) DOI： 10.13406/j.cnki.cyxb.2000.02.001.

摘要

目的 :研究孕妇HCMV感染对胚胎染色体着丝粒点（Cd）变异的影响

探讨HCMV感染引起出生缺陷的原因和机制。方法 :用我室改良的Cd -NOR同步银染技术对 15例HCMV感染和 2 5例非感染孕妇的胚胎或绒毛组织Cd消失、Cd变异进行比较分析。结果 :前者Cd消失、Cd变异频率较后者有显著和极显著的增高。结论 :染色体Cd的变化可能是HCMV感染引起胚胎发育异常的重要原因之一

对HCMV感染孕妇的胚胎或绒毛组织进行染色体Cd分析对评价胚胎进一步发育可能受累的风险和优生优育具有重要的临床意义

Abstract

Objective:We studied the relationship between the infection of HCMV and the variation of kinetochore

researched the mechanism of causing abnormal growth embryo. Methods:Kinetochore (centromeric dots

Cd) of chorionic villus or embryo tissue of 15 HCMV-DNA(PCR) positive and 25 HCMV-DNA(PCR) negative pregnant women were studied by Cd-banding techniques. Results:The frequency of Cd loss and Cd size variation in positive group were significantly higher than those in negative group. Conclusion:The study indicated that Cd variation caused by HCMV infection play an important role in form of birth defect. Cd banding analysis in chorionic villus or embryo tissue of HCMV-DNA(PCR) positive pregnant women could evaluate the risk of abnormal growth embryo.

关键词

着丝粒点巨细胞病毒胚胎产前诊断

Keywords

KinetochoreCytomegalovirusembryoprenatal diagnosis

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