Relationship between circulating nitric oxide level and autonomic neuropathy in diabetic patients

WANG Yu-jun; et al

doi:10.13406/j.cnki.cyxb.2000.01.018

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Relationship between circulating nitric oxide level and autonomic neuropathy in diabetic patients

更新时间：2024-01-17

- Relationship between circulating nitric oxide level and autonomic neuropathy in diabetic patients
- Journal of Chongqing Medical University Issue 1, Pages: 53-55(2000)
- 作者机构：
  
  重庆医科大学第二临床学院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.018
  CLC： R587.1
- Published：2000，
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[1]王玉君,刘东方,严钟德,李荣.糖尿病患者一氧化氮与自主神经病变的关系[J].重庆医科大学学报,2000(01):53-55.

WANG Yu-jun, et al. Relationship between circulating nitric oxide level and autonomic neuropathy in diabetic patients. [J]. Journal of Chongqing Medical University (1):53-55(2000)
[1]王玉君,刘东方,严钟德,李荣.糖尿病患者一氧化氮与自主神经病变的关系[J].重庆医科大学学报,2000(01):53-55. DOI： 10.13406/j.cnki.cyxb.2000.01.018.

WANG Yu-jun, et al. Relationship between circulating nitric oxide level and autonomic neuropathy in diabetic patients. [J]. Journal of Chongqing Medical University (1):53-55(2000) DOI： 10.13406/j.cnki.cyxb.2000.01.018.

摘要

为探讨一氧化氮（ＮＯ）与糖尿病自主神经病变（ＤＡＮ）的关系，本研究用镀铜镉还原法测定了７０例２型糖尿病（ＤＭ）及４０例正常对照ＮＯ稳定代谢产物ＮＯ－２，并用心率功率谱分析测定了ＤＭ患者自主神经功能，将ＤＭ患者分为伴ＤＡＮ和无ＤＡＮ组。结果显示伴ＤＡＮ的ＤＭ患者血ＮＯ显著低于无ＤＡＮ的ＤＭ患者及正常对照，而其ＨｂＡｌｃ、ＴＧ、ＴＣ、血压较无ＤＡＮ者及正常对照者高，相关分析显示ＮＯ与Ｐｖｖ、Ｐｈｖ、Ｔｆｐ呈正相关，与ＨｂＡｌｃ、ＴＧ、ＴＣ、病程、血压呈负相关。多元逐步回归分析显示Ｐｖｖ、Ｐｈｖ、血压是与ＮＯ显著相关的因素。本研究提示ＮＯ水平的下降可能是引起ＤＡＮ的重要因素之一，ＤＭ患者ＮＯ水平的下降与长期代谢紊乱有关。

Abstract

To investigate the role of nitric oxide (NO) in the pathogenesis of diabetic autonomic neuropathy (DAN)

the circulating levels of nitrite(NO-2) stable metabolic product of NO and autonomic nerve function(ANF) were measured in 40 normal subjects and 70 type 2 DM patients. The DM patiellts were divided into 40 patients with DAN and 30 patients without DAN. We found that NO concentration was markedly decreased in patients with DAN compared with normal subjects and patients without DAN

while the HbA1c、 TG、 TC and blood pressure were higher than for normal subjects and patients Without DAN.There was remarkable positive correlation between NO and Pvv. Phv and Tfp

and significant negative correlation between NO levels and HbAlc’ TG’ TC、 blood pressure and duration.Multiple linear regression suggested blood pressure

Pvv and Phv were significantly related to NO. The results suggest that decreased NO levels play important roles in the initiation and progression of DAN and is related to poor metabolic control of DM.

关键词

NO自主神经病变糖尿病

Keywords

NODANDM

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