Effect of selenium supplementation on transplantive tumor growth and lymphocyte functions in mice

CHENG Dao-sheng; et al

doi:10.13406/j.cnki.cyxb.2000.01.014

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Effect of selenium supplementation on transplantive tumor growth and lymphocyte functions in mice

更新时间：2024-01-17

- Effect of selenium supplementation on transplantive tumor growth and lymphocyte functions in mice
- Journal of Chongqing Medical University Issue 1, Pages: 41-43(2000)
- 作者机构：
  
  重庆医科大学检验医学系临床免疫教研室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.014
  CLC： R730.3
- Published：2000，
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[1]程道胜,邓一平,卢贤瑜.补硒对小鼠移植瘤生长及淋巴细胞功能的影响[J].重庆医科大学学报,2000(01):41-43.

CHENG Dao-sheng, et al. Effect of selenium supplementation on transplantive tumor growth and lymphocyte functions in mice. [J]. Journal of Chongqing Medical University (1):41-43(2000)
[1]程道胜,邓一平,卢贤瑜.补硒对小鼠移植瘤生长及淋巴细胞功能的影响[J].重庆医科大学学报,2000(01):41-43. DOI： 10.13406/j.cnki.cyxb.2000.01.014.

CHENG Dao-sheng, et al. Effect of selenium supplementation on transplantive tumor growth and lymphocyte functions in mice. [J]. Journal of Chongqing Medical University (1):41-43(2000) DOI： 10.13406/j.cnki.cyxb.2000.01.014.

摘要

用灌胃方法给小鼠补充Ｎａ

２

ＳｅＯ

３

６μｇ／ｄ和１２μｇ／ｄ，６周后皮下移植Ｓ１８０肉瘤细胞，观察肿瘤发生生长情况及脾脏淋巴细胞转化功能和ＣＴＬ杀伤活性。结果显示，补硒组肿瘤生长速度及平均瘤重均明显低于未补硒的肿瘤对照组，补硒组小鼠脾脏淋转率和ＣＴＬ杀伤活性均明显高于肿瘤对照组。瘤重与ＣＴＬ杀伤活性之间呈负相关关系。提示补硒具有抑制肿瘤生长的作用，该作用与硒能促进脾脏淋巴细胞功能有关。

Abstract

To eveluate the effct of selenium supplementation on tumor immunity

S180 cells were transplanted subcutaneously into three groups of mice

two of them(Se-Ⅰ

and Se-Ⅱ)have been gavaged with selenium(6μ g/day

or 12μg/day) for 6 weeks.At the 13th day after S180 cells were trsnsplanted

tumor growth and spleen cellular immunity were analyzed.The results showed that tumor growth was inhibited and splenic lymphocyte transformation and CTL activity were enhanced significantly in selenium supplemefltation groups as compared to tumor-bearing control.Significant negative correlation was found between inhibition and enhancement(r=-0.67

P< 0.005).The study suggests that selenium supplementation can inhibit transplantive tumor growth

and that this effect is related to its ability to enhance splenic lymphocyte functions.

关键词

硒肿瘤细胞免疫

Keywords

SeleniumPneoplasmcellular immunity

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Related Institution

Department of Laboratory Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine

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重庆医科大学检验系临床免疫学教研室

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