Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus

CHEN Ya-xi; et al

doi:10.13406/j.cnki.cyxb.2000.01.013

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Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus

更新时间：2024-01-17

- Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus
- Journal of Chongqing Medical University Issue 1, Pages: 39-40(2000)
- 作者机构：
  
  重庆医科大学病毒性肝炎研究所,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.013
  CLC： R512.62
- Published：2000，
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[1]陈压西,郭树华,齐珍元,张定凤.广西叶下珠抗鸭乙型肝炎病毒的实验研究[J].重庆医科大学学报,2000(01):39-40.

CHEN Ya-xi, et al. Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus. [J]. Journal of Chongqing Medical University (1):39-40(2000)
[1]陈压西,郭树华,齐珍元,张定凤.广西叶下珠抗鸭乙型肝炎病毒的实验研究[J].重庆医科大学学报,2000(01):39-40. DOI： 10.13406/j.cnki.cyxb.2000.01.013.

CHEN Ya-xi, et al. Experimental study on the effect of Guangxi phyllanthus urinaria on anti-duck hepatitis B virus. [J]. Journal of Chongqing Medical University (1):39-40(2000) DOI： 10.13406/j.cnki.cyxb.2000.01.013.

摘要

用重庆麻鸭乙型肝炎动物模型，观察广西叶下珠体内抗鸭乙型肝炎病毒（ＤＨＢＶ）的作用。用广西叶下珠治疗１月，检测用药前后血清中的ＤＨＢＶＤＮＡ及转氨酶、肝组织病理等。广西叶下珠用药２周、１月能使血清ＤＨＢＶＤＮＡ总体水平显著降低（Ｐ＜０．０５或Ｐ＜０．０１），且停药后ＤＮＡ滴度回升不明显。血清转氨酶检查及肝脏常规ＨＥ染色病理检查未发现叶下珠对肝脏有明显的毒性损害。广西叶下珠在体内有抗鸭乙型肝炎病毒的作用。

Abstract

The purpose of this work was to study the effect of Guangxi Phyllanthus urinaria on anti-duck hepatitis virus(DHBV) in vivo and provide an experimental basis for clinical treatment of patients with hepatitis B. The Chongqing duck hepatitis B virus model was treated with Phyllanthus urinaria once a day for a month at doses of 1g/kg、 5g/kg、10g/kg of body weight. DHBV DNA in serum was detected four times from the beginning to the end of the treatment

ALT and AST in serum were detected simultaneously. Phyllanthus urinaria could significantly lower the serum DHBV DNA level. After 1 week stopping treatment

serum DHBV DNA concentrations in Phyllanthus urinaria-treated ducks did not increase significamly. The study confirms the safety and potent antihepadnaviral activity of Phyllanthus urinaria in vivo.

关键词

广西叶下珠鸭乙型肝炎病毒动物模型

Keywords

Phyllanthus urinariaDuck hepatitis B virusanimal model

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Zhang Binghan

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Related Institution

Institute of Viral Hepatitis,Chongqing Medical University

重庆医科大学病毒性肝炎研究所

Department of Endocrinology，Chongqing Traditional Chinese Medicine Hospital

Department of Endocrinology，The Second Affiliated Hospital of Chongqing Medical University

Department of Dermatology,The First Affiliated Hospital of Chongqing Medical University

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