Effects of tetrandrine on calcium channels in rat cortical neurons

WANG Zhong-Feng; et al

doi:10.13406/j.cnki.cyxb.2000.01.006

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Effects of tetrandrine on calcium channels in rat cortical neurons

更新时间：2024-01-17

- Effects of tetrandrine on calcium channels in rat cortical neurons
- Journal of Chongqing Medical University Issue 1, Pages: 18-19(2000)
- 作者机构：
  
  1. 中国科学院上海生理研究所,200030
  2. 重庆医科大学基础医学院生化药理研究室,400016
  3. 中国科学院上海生理研究所!200030重庆医科大学基础医学院生化药理研究室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.006
  CLC： R285
- Published：2000，
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[1]王中锋,薛春生,周歧新.汉防己碱对大鼠皮层神经元钙通道的阻滞作用[J].重庆医科大学学报,2000(01):18-19+3.

WANG Zhong-Feng, et al. Effects of tetrandrine on calcium channels in rat cortical neurons. [J]. Journal of Chongqing Medical University (1):18-19(2000)
[1]王中锋,薛春生,周歧新.汉防己碱对大鼠皮层神经元钙通道的阻滞作用[J].重庆医科大学学报,2000(01):18-19+3. DOI： 10.13406/j.cnki.cyxb.2000.01.006.

WANG Zhong-Feng, et al. Effects of tetrandrine on calcium channels in rat cortical neurons. [J]. Journal of Chongqing Medical University (1):18-19(2000) DOI： 10.13406/j.cnki.cyxb.2000.01.006.

摘要

在急性分离的大鼠大脑皮层神经元上，用膜片钳单通道记录技术研究汉防己碱（Ｔｅｔ）对电压依赖性钙通道的影响。结果表明，Ｔｅｔ７．５ μ ｍｏｌ／Ｌ、１５μｍｏｌ／Ｌ和３０μｍｏｌ／Ｌ可浓度依赖性抑制大鼠皮层神经元膜Ｌ－和Ｎ－型电压依赖性钙通道，使其开放时间缩短，关闭时间延长，开放概率降低，从而降低钙内流，其对Ｌ－型钙通道的作用与钙通道阻滞剂Ｖｅｍｐａｍｉｌ相似但较弱。Ｔｅｔ的多种药理作用可能与其阻滞钙通道有关。

Abstract

The effects of tetrandrine (Tet ) on calcium channels in acutely isolated rat conical neurons were studied using the patch clamp single channel recording technique. The results indicated that Tet (7.5μ moll

15 μ moll and 30 μ mol/L ) inhibited the L- and N- type calcium channels in a concentration-dependent manner. The open times of L- and N- type calcium channels decreased

the closed times increased

and open-state probability decreased. The effects of Tet on L-type calcium charmel were consistent with verapamil

a typical calcium channel antagonist

but were weaker than those of verapamil. On the other hands

the N-type calcium channel blocking effects of Tet were much stronger than those of verapamil. The multifunctions of Tet might be related to its antagonist effect on the calcium charmels.

关键词

汉防己碱膜片钳钙离子通道皮层神经元大鼠

Keywords

Tetrandrinepatch clampcalciumIon channelCortical neuronrat

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