Effects of some factors on the release of adrenomedullin and adrenotensin from rat aorta

ZHOUL Lan; et al

doi:10.13406/j.cnki.cyxb.2000.01.004

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Effects of some factors on the release of adrenomedullin and adrenotensin from rat aorta

更新时间：2024-01-17

- Effects of some factors on the release of adrenomedullin and adrenotensin from rat aorta
- Journal of Chongqing Medical University Issue 1, Pages: 10-13(2000)
- 作者机构：
  
  1. 重庆医科大学基础医学院分子生物学教研室,400046
  2. 广东医学院解剖教研室,524023
  3. 重庆医科大学中心实验室,400016
  4. 北京医科大学心血管基础所,100083
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.01.004
  CLC： R33
- Published：2000，
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[1]周兰,叶赤,邱宗荫,唐朝枢,赵云涛.影响大鼠主动脉肾上腺髓质素和肾上腺升压素释放的因素[J].重庆医科大学学报,2000(01):10-13.

ZHOUL Lan, et al. Effects of some factors on the release of adrenomedullin and adrenotensin from rat aorta. [J]. Journal of Chongqing Medical University (1):10-13(2000)
[1]周兰,叶赤,邱宗荫,唐朝枢,赵云涛.影响大鼠主动脉肾上腺髓质素和肾上腺升压素释放的因素[J].重庆医科大学学报,2000(01):10-13. DOI： 10.13406/j.cnki.cyxb.2000.01.004.

ZHOUL Lan, et al. Effects of some factors on the release of adrenomedullin and adrenotensin from rat aorta. [J]. Journal of Chongqing Medical University (1):10-13(2000) DOI： 10.13406/j.cnki.cyxb.2000.01.004.

摘要

用放射免疫法测定离体大鼠主动脉孵育或灌流介质中肾上腺髓质素（ＡＭ）和肾上腺升压素（ＡＴ），发现：①１～１００ｎｍｏｌ／ＬＡＩＩ和ＥＴ－１呈剂量依赖性增加ＡＭ的释放率；１和１０ｎｍｏｌ／ＬＡⅡ和ＥＴ－１对ＡＴ的释放无明显影响，１００ｎｍｏｌ／ＬＡⅡ和ＥＴ－１则增加ＡＴ释放率；这六组的ＡＮ／ＡＴ比值均增大；②１０ｎｍｏｌ／Ｌ肾上腺素增加ＡＭ和ＡＴ的释放率，１０ｎｍｏｌ／ＬＣＧＲＰ则降低两者的释放率，它们的ＡＭ／ＡＴ比值不变；③１μｇ／ｍｌ　ＬＰＳ对两者的释放无影响，但５和１０μｇ／ｍｌＬＰＳ则增加ＡＭ、ＡＴ释放率３９％和７４％以及ＡＭ／ＡＴ比值；④缺氧只抑制ＡＴ的释放，致比值增大；⑤流速加快增加ＡＭ和ＡＴ的释放率，但比值不变；流速减慢对两者的释放无影响。提示：ＡⅡ、ＥＴ－１、肾上腺素、ＣＧＲＰ、ＬＰＳ、流速和氧供可能是ＡＭ和ＡＴ释放的调节因素。

Abstract

Incubation and perfusion of isolated rat aorta and radioimmunoassay of adrenomedullin(AM) and adrenotensin(AT) in the media were used to investigate the factors which influence the release of AM and AT from rat aorta. We found that: ①angiotensin Ⅱ(A Ⅱ) and endothein-1(ET-1) at doses of 1 - 100 nmol/m increased AM release rate in a dose-dependent mariner; 1 and 10 nmol/L AⅡ and ET-1 had no obvious effects on AT release

100 nmol/L A Ⅱ and ET-1 increased AT release rate; the six AM/AT ratios increased; ② 10 nmoll epinephrine augmented release rates of AM and AT and 10nmol/L calcitonin gene related peptide(CGRP) decreased the release rate same degree; the two AM/AT ratios were not changed; ③ Iμ/ml lipopolysaccharide(LPS) had no effect on the release rates; but 5 and 10μ g/ml LPS increased release rates of AM and AT and the AM/AT ratios; ④ Hypoxia inhibited only AT release

thus increasing the AM/AT ratio; ⑤ Increase of flow rate augmented release rates of AM and AT

but did not change their ratio; decrease of flow rate had no effect on their release rates. These data suggest that A Ⅱ

ET-1

epinephrine

CGRP

LPS

oxygen supply and flow tale may be the factors participating in the regulation of AM and AT release from rat aorta.

关键词

肾上腺髓质素肾上腺升压素释放调节

Keywords

AdrenomedullinAdrenotensinRelease regulation

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