Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye

Yang Shuqun; et al

doi:10.13406/j.cnki.cyxb.1999.04.014

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Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye

更新时间：2024-01-17

- Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye
- Journal of Chongqing Medical University Issue 4, Pages: 376-380(1999)
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- DOI：10.13406/j.cnki.cyxb.1999.04.014
  CLC： R969.1
- Published：1999，
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[1]杨淑群,周远大,何海霞.家兔静注环丙沙星后眼组织分布及其药代动力学研究[J].重庆医科大学学报,1999(04):376-380.

Yang Shuqun, et al. Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye. [J]. Journal of Chongqing Medical University (4):376-380(1999)
[1]杨淑群,周远大,何海霞.家兔静注环丙沙星后眼组织分布及其药代动力学研究[J].重庆医科大学学报,1999(04):376-380. DOI： 10.13406/j.cnki.cyxb.1999.04.014.

Yang Shuqun, et al. Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye. [J]. Journal of Chongqing Medical University (4):376-380(1999) DOI： 10.13406/j.cnki.cyxb.1999.04.014.

摘要

家兔静注环丙沙星（ＣＰＦＸ）后，用高效液相色谱仪测定眼内各组织中药物浓度。环丙沙星在泪液、角膜、房水、虹膜－睫状体、晶体和玻璃体组织内峰浓度值分别为８．９２±２．８８、１４２．８４±２５．０２、１１．０６±２．８０、９９．３２±１０．６０、３０．２８±１．９１和８．１０±１．７１ｕｇ／ｇ：ｍｌ；其各组织中半衰期分别为１．４９±０．９７、１６６±０．１３、２．０９±０．５１、２．０１±０．４４、１．５２±０．９２和１．２１±０．６６ｈ。结果表明ＣＰＦＸ静注后能穿透到各眼内组织中。

Abstract

The intraocular concentration of ciprofloxacin was measured by high performance liquid chromatographyafter single intravenous injection ciprofloxacin in the rabbit eye. The peak concentrations (Cmax) ofciprofloxacin in lachrymal fluid

cornea

aqueous humour

iris - ciliary body

lens

vitreous body were 8.92±2.88

142.84±32.02

11.06±2.80

99.32±10.60

30.28±1.91 and 8.10±1.71ug/g. ml

respectively. The half - life(t1/2 ) ofvarious concentrations in lachrymal fluid

cornea

aqueous humour

iris-ciliary body

lens and vitreous bodywas 1.49± 0.97

1.66±10.13

2.09±0.51

2.01±0.44

1.52±0.92 and 1.21±0.66h

respectively. The results indicate thatciprofloxacin can penetrate intraocular various tissure.

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环丙沙星组织分布药代动力学高效液相色谱法

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