Prolongation of cardiac xenografts in guineapig to rat combination by CCV treatment

Du Chengyou; et al

doi:10.13406/j.cnki.cyxb.1999.04.009

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Prolongation of cardiac xenografts in guineapig to rat combination by CCV treatment

更新时间：2024-01-17

- Prolongation of cardiac xenografts in guineapig to rat combination by CCV treatment
- Journal of Chongqing Medical University Issue 4, Pages: 363-365(1999)
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- DOI：10.13406/j.cnki.cyxb.1999.04.009
  CLC： R617
- Published：1999，
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[1]杜成友,姚榛祥,周洪伟.中华眼镜蛇毒治疗对豚鼠移植于大鼠心脏存活时间的影响[J].重庆医科大学学报,1999(04):363-365.

Du Chengyou, et al. Prolongation of cardiac xenografts in guineapig to rat combination by CCV treatment. [J]. Journal of Chongqing Medical University (4):363-365(1999)
[1]杜成友,姚榛祥,周洪伟.中华眼镜蛇毒治疗对豚鼠移植于大鼠心脏存活时间的影响[J].重庆医科大学学报,1999(04):363-365. DOI： 10.13406/j.cnki.cyxb.1999.04.009.

Du Chengyou, et al. Prolongation of cardiac xenografts in guineapig to rat combination by CCV treatment. [J]. Journal of Chongqing Medical University (4):363-365(1999) DOI： 10.13406/j.cnki.cyxb.1999.04.009.

摘要

本实验选用豚鼠移植于大鼠异种心脏移植模型，观察移植术前３日及术日中华眼镜蛇毒（ｃｈｉｎｅｓｅｃｏ－ｂｒａｖｅｎｏｍ，ＣＣＶ）０．２ｍｇ·ｋｇ－１·ｄ－１腹腔注射对豚鼠移植于大鼠心脏存活时间的影响。结果显示：围手术期ＣＣＶ治疗能使移植豚鼠心脏存活达１８±１０．２小时，与单纯豚鼠移植于大鼠心脏存活时间０．２５±０．１２小时比较，差异显著（Ｐ＜０．０１）。单纯豚鼠移植于大鼠心脏被排斥时，组织病理学表现为超急性排斥反应，即心肌细胞溶解坏死，间质出血，血栓形成，未见炎性细胞浸润，大量补体Ｃ３沉积；而ＣＣＶ治疗下移植心脏被排斥时除有心肌细胞坏死，间质出血外，尚有大量的单核细胞浸润，未见补体Ｃ３沉积。上述结果表明，ＣＣＶ治疗能显著延长异种移植心脏存活时间，与其清除Ｃ３作用有关。

Abstract

In an in vivo guineapig to rat cardiac xenotransplantation model

the prolongation of cardiac xenograft bychinese cobra venom(CCV) was studied. The rats were divided into a control and 2 experimentalgroups.technical control (group A); no treatment (group B) and CCV treatment(group C). Rats were given i.p. of0.2mg. kg-1 . d-1. CCV on day - 3

- 2

- 1 and day 0 relative to heart grafting. The therapy using CCV induced18t10.2hrs graft survival (P<0.01 Vs 0. 25± 0.12h in group B) .Histologic and immunohistologic analysis onrejected hearts revealed the typical lesion of hyperacute rejection and massive C3 deposition in group B

andinterstitial heamorrhge

myocytolysis and a large humber of monocyte infilitration in group C. Our study showedCCV treatment is effective in prolonging the survival time of guineapig cardiac xenografts.

关键词

蛇毒异种心脏移植存活时间

Keywords

Cobra venomCardiac xenotransplantationSurvival

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