Detection of antibody against E2 glycoprotein in sera from hepatitis C patients

Zhu Chaomin; et al

doi:10.13406/j.cnki.cyxb.1999.03.014

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Detection of antibody against E2 glycoprotein in sera from hepatitis C patients

更新时间：2024-01-17

- Detection of antibody against E2 glycoprotein in sera from hepatitis C patients
- Journal of Chongqing Medical University Issue 3, Pages: 262-263(1999)
- 作者机构：
  
  北京医科大学人民医院肝病研究所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1999.03.014
  CLC： R512.63
- Published：1999，
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[1]朱朝敏,吴朝栋,陶其敏.丙型肝炎患者抗E2抗体的初步检测及其意义[J].重庆医科大学学报,1999(03):262-263.

Zhu Chaomin, et al. Detection of antibody against E2 glycoprotein in sera from hepatitis C patients. [J]. Journal of Chongqing Medical University (3):262-263(1999)
[1]朱朝敏,吴朝栋,陶其敏.丙型肝炎患者抗E2抗体的初步检测及其意义[J].重庆医科大学学报,1999(03):262-263. DOI： 10.13406/j.cnki.cyxb.1999.03.014.

Zhu Chaomin, et al. Detection of antibody against E2 glycoprotein in sera from hepatitis C patients. [J]. Journal of Chongqing Medical University (3):262-263(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.014.

摘要

为了探讨急、慢性丙型肝炎病人血清抗E2抗体的临床意义．用哺乳动物细胞表达的E2抗原，通过Westernblot检测丙型肝炎病人血清中抗E2抗体。结果37份急慢性丙型肝炎病人血清抗E2抗体在HCVRNA阳性者中检测为59.5％，其中急性患者中检出率为30％，慢性患者中检出率为70．3％。提示抗E2抗体可以作为检测HCV感染有价值诊断指标之一。

Abstract

Antibody response against E2 glycoprotein in hepatitis C virus was studied in 37 patients with acute orchronic hepatitis C. E2 glycoprotein expressed in mammalian cells was used to detect specific antibody (anti-E2)in samples obtained by Western blot from patients with acute and chronic hepatitis C.These results showed thatanti-E2 could be detected in 59.5% of the patients including 3 of 10 acute patients and 19 of 27 chronic patients.It is suggested thatanti-E2 is an useful marker for determining HCV.

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丙型肝炎E2糖蛋白血清学检测

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DETECTION OF SERUM HEPATITIS C VIRAL RNA IN PATIENTS WITH HEPATIC FAILURE BY "NESTED" POLYMERASE CHAIN REACTION

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重庆医科大学第二医院病毒性肝炎研究所

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