The cytotoxic effect of aspirin on human gastric cancer cell lines SGC-7901 in vitro

Gao Qing; et al

doi:10.13406/j.cnki.cyxb.1999.03.013

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The cytotoxic effect of aspirin on human gastric cancer cell lines SGC-7901 in vitro

更新时间：2024-01-17

- The cytotoxic effect of aspirin on human gastric cancer cell lines SGC-7901 in vitro
- Journal of Chongqing Medical University Issue 3, Pages: 259-261(1999)
- 作者机构：
  
  重庆市急救中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1999.03.013
  CLC： R735.2
- Published：1999，
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[1]高青,唐承薇,刘兴.阿斯匹林对胃癌细胞株SGC—7901的体外细胞毒作用[J].重庆医科大学学报,1999(03):259-261.

Gao Qing, et al. The cytotoxic effect of aspirin on human gastric cancer cell lines SGC-7901 in vitro. [J]. Journal of Chongqing Medical University (3):259-261(1999)
[1]高青,唐承薇,刘兴.阿斯匹林对胃癌细胞株SGC—7901的体外细胞毒作用[J].重庆医科大学学报,1999(03):259-261. DOI： 10.13406/j.cnki.cyxb.1999.03.013.

Gao Qing, et al. The cytotoxic effect of aspirin on human gastric cancer cell lines SGC-7901 in vitro. [J]. Journal of Chongqing Medical University (3):259-261(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.013.

摘要

近年研究表明非甾体类抗炎药物对某些肿瘤具有抑制作用。本文采用噻唑蓝体外细胞毒试验（MTT），观察阿斯匹林对人胃癌细胞株SGC－7901的生长抑制作用。结果表明：阿斯匹林对SGC－7901生长有明显的抑制作用，其抑制率与阿斯匹林浓度和作用时间呈正相关性（r分别为0．8873和0．8256，P值均小于0．001）。小剂量阿斯匹林联合5－Fu作用于SGC－7901，其生长抑制率有明显提高。结论：阿斯匹林具有抑制人胃癌细胞株SGC－7901生长的作用，与5－Fu联用效果更佳。

Abstract

The inhibitory effects of aspirin on the growth of human gastric cancer ce1l lines SGC - 7901were studied byusing MTT assay in vitro. The results showed that the growth of SGC-7901 was greatly inhibited by31.25mmol/L aspirin. The inhibitory rates for growth of SGC-7901 were positively correlated with theconcentration (r=0.8873 ) and duration (r=0.8256 ) of aspirin in the media. The combination of aspirin in lowconcentration with 5-Fluororacil (5-Fu) showed a synergistic inhibitory effect on the growth of SGC-7901.Inconclusion

aspirin inhibited the growth of human gastric cancer cell lines SGC-7901 and had betterinhibitory effects when combined with 5-Fu.

关键词

胃癌阿斯匹林噻唑蓝还原法

Keywords

gastric cancerAspirinMTT

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