Prophylactic protective mechenism of EGL on ischemic damage in rat brain

Xa Yilu; et al

doi:10.13406/j.cnki.cyxb.1999.03.012

您当前的位置：

首页 >

文章列表页 >

Prophylactic protective mechenism of EGL on ischemic damage in rat brain

更新时间：2024-01-17

- Prophylactic protective mechenism of EGL on ischemic damage in rat brain
- Journal of Chongqing Medical University Issue 3, Pages: 256-258(1999)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1999.03.012
  CLC： R285
- Published：1999，
扫描看全文
[1]夏一鲁,胡常林,董为伟.灵芝保护鼠脑缺血性损害的作用机制[J].重庆医科大学学报,1999(03):256-258.

Xa Yilu, et al. Prophylactic protective mechenism of EGL on ischemic damage in rat brain. [J]. Journal of Chongqing Medical University (3):256-258(1999)
[1]夏一鲁,胡常林,董为伟.灵芝保护鼠脑缺血性损害的作用机制[J].重庆医科大学学报,1999(03):256-258. DOI： 10.13406/j.cnki.cyxb.1999.03.012.

Xa Yilu, et al. Prophylactic protective mechenism of EGL on ischemic damage in rat brain. [J]. Journal of Chongqing Medical University (3):256-258(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.012.

摘要

为探讨灵芝水溶性提取物（EGL）对鼠脑缺血性损害的预防性保护机制，检测了大鼠脑梗塞区rCBF、SOD、Na+－K+－ATP酶活性。结果显示预防性使用EGL组较梗塞后使用组的SOD、Na+－K+-ATP酶活性更高，rCBF改善仅出现于梗塞后第五天，且与梗塞体积缩小和组织学恢复无关。提示保护SOD、Na+－K+－ATP酶可能是EGL发挥其预防性保护作用的机制之一。

Abstract

To investigate the prophylactic protective mechanism of the water soluble extract of GanodermaLucidum(EGL) on ischemic cerebral damage in rats

the rats were fed with EGL prior and posterior to cerebralischemia induced by photochemical technique.SOD and Na+-K+-ATPase activity in brain homogenate weremeasured

and rCBF was recorded.The results showed that the ascension of rCBF presented only at the 5th day

andso

was not related with the diminished infarction volume and the histomorphological recovery in rat brains atearly stages.SOD activity of the pretreated group was higher than those of control and treat groups

as was Na+K+-ATPase activity.The results suggest that EGL administered before cerebral infarction in rats may havecerebral protective effects at eraly stages by maintaining SOD and Na+-K+- ATPase activity in ischemic tissue.

关键词

灵芝预防性神经保护脑缺血超氧化物歧化酶钠钾三磷酸腺苷酶

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

EVALUATION FOR FIVE INDICATORS FOR AGING

HEPATIC MITOCHONDRIA DAMAGE AND LIPID PEROXIDATION INDUCED BY ENDOTOXIN

Analysis of glutathione peroxidase，superoxide dismutase and malondialdehyde concentration in gingival crevicular fluid in patients with human peri-implantitis

Related Author

王荣光

王霞文

Gao Aiguo

et al

Chen Chunzhi

Xu Ling

Hu Changhong

Zhang Yi

Related Institution

重庆医科大学检验系

Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences，Department of Prosthetics，The Affiliated Hospital of Stomatology，Chongqing Medical University

⁰