Study of the mechanism of transient T lymphocyte dysfunction in neonates

Liu Enmei; et al

doi:10.13406/j.cnki.cyxb.1999.03.011

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Study of the mechanism of transient T lymphocyte dysfunction in neonates

更新时间：2024-01-17

- Study of the mechanism of transient T lymphocyte dysfunction in neonates
- Journal of Chongqing Medical University Issue 3, Pages: 253-255(1999)
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- DOI：10.13406/j.cnki.cyxb.1999.03.011
  CLC： R722.1
- Published：1999，
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[1]刘恩梅,李成荣,杨锡强,王莉佳.新生儿T细胞功能暂时性低下机理探讨[J].重庆医科大学学报,1999(03):253-255.

Liu Enmei, et al. Study of the mechanism of transient T lymphocyte dysfunction in neonates. [J]. Journal of Chongqing Medical University (3):253-255(1999)
[1]刘恩梅,李成荣,杨锡强,王莉佳.新生儿T细胞功能暂时性低下机理探讨[J].重庆医科大学学报,1999(03):253-255. DOI： 10.13406/j.cnki.cyxb.1999.03.011.

Liu Enmei, et al. Study of the mechanism of transient T lymphocyte dysfunction in neonates. [J]. Journal of Chongqing Medical University (3):253-255(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.011.

摘要

本文通过观察经anti-CD3活化后脐血淋巴细胞（CBMC）内钙离子（Ca2+）浓度、蛋白激酶（PKC）激动剂PMA对CBMCIL-2mRNA表达、增殖反应及凋亡的影响，进一步探讨新生儿T细胞（TL）功能暂时性低下的机理。结果发现经anti-CD3刺激后，CBMCCa2+明显升高，与成人外周血淋巴细胞（PBMC）无明显差异（P＞0．05）。PKA不仅可纠正anti-CD3诱导的CBMC凋亡，而且显著提高anti－CD3诱导的新生儿TL增殖反应及IL-2mRNA表达，提示CBMCCa2+／PKC信号传导不平衡是其活化、增殖功能低下，易于调亡的生理基础，推测CBMCPKC产生不足与其TL表型有关．

Abstract

In order to study the mechanism of transient T lymphocyte dysfunction in neonates

we observedthe concentration of cytosolic calcium

the effects of PMA (which is an activator of protein kinase (PKC) on IL-2mRNA expression)

and apoptosis in core blood mononuclear cells(CBMC) after stimmulation by anti-CD3. Thedata showed that the cytosolic calcium concentration of CBMC increased after stimulation by anti-CD3

butthere was no difference compared with adult peripheral blood mononuclear cell(PBMC).PMA not only correctedapoptosis of CBMC

but also enhanced TL proliferation and IL-2 mRNA expression in induced by anti-CO3 inneonate.These results suggested that Ca2+/PKC signal thansduction iln balance of CBMC may be thephysiological basis of low activation

proliferation and tendency towards apoptosis.

关键词

新生儿细胞因子凋亡信号传导

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