The expression of basic fibroblast growth factor(bFGF)and FGFR-1 in renal tubulointerstitial fibrosis

Xu Man

doi:10.13406/j.cnki.cyxb.1999.03.006

您当前的位置：

首页 >

文章列表页 >

The expression of basic fibroblast growth factor(bFGF)and FGFR-1 in renal tubulointerstitial fibrosis

更新时间：2024-01-17

- The expression of basic fibroblast growth factor(bFGF)and FGFR-1 in renal tubulointerstitial fibrosis
- Journal of Chongqing Medical University Issue 3, Pages: 239-241(1999)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1999.03.006
  CLC： R392.11
- Published：1999，
扫描看全文
[1]徐曼.成纤维细胞生长因子及受体在肾小管间质纤维化过程中的表达[J].重庆医科大学学报,1999(03):239-241.

Xu Man. The expression of basic fibroblast growth factor(bFGF)and FGFR-1 in renal tubulointerstitial fibrosis. [J]. Journal of Chongqing Medical University (3):239-241(1999)
[1]徐曼.成纤维细胞生长因子及受体在肾小管间质纤维化过程中的表达[J].重庆医科大学学报,1999(03):239-241. DOI： 10.13406/j.cnki.cyxb.1999.03.006.

Xu Man. The expression of basic fibroblast growth factor(bFGF)and FGFR-1 in renal tubulointerstitial fibrosis. [J]. Journal of Chongqing Medical University (3):239-241(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.006.

摘要

利用免疫组织化学及原位杂交技术观察30例肾间质纤维化模型大鼠，探讨碱性成纤维细胞生长因子（bFG）及受体（FGFR－1）与肾小管间质纤维化的关系。结果显示大鼠模型中损伤的肾小管上皮过度表达bFGF、FGFR－1，且合成Ⅲ型胶元；肾间质细胞广泛表达bFGF和FGFR－1，而且此表达程度和间质细胞核增殖及小管间质Ⅲ型胶元沉积程度一致．本实验证实肾小管损伤刺激bFGF、FGFR－1的分泌，提示bFGF可能通过自分泌和（或）旁分泌机制促进肾小管上皮的再生修复、间质细胞的增殖及Ⅲ型胶元的合成，从而促进肾小管间质纤维化的形成。

Abstract

The relationship between the expression of bFGF

FGFR-1 and renal tubulointerstitial fibrosis wasinvestigated by using immunohistochemistry and in situ hybridization techniques in thirty rat renaltubulointerstitial fibrosis models. The results showed that injured tubular cells excessively synthesized bFGF

FGFR- 1 and collagen IH; in addition

interstitial celIs widely expressed bFGF and FGFR- 1

their degree ofexpression accorded with PCNA expression in these cells and with collagen III deposition in thetubulointerstitium.It suggested that injury to tubular cells enhenced the secretion of bFGF and FGFR- 1.bFGFprobably promoted the regeneration of injured tubular celIs

the proliferation of interstitial cells and the synthzsisof collagen III through autocrine and/or paracrine mechanism

and thus accelerated the fibrosis of the renalinterstitium.

关键词

碱性成纤维细胞生长因子成纤维细胞生长因子受体-1肾小管间质纤维化

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰