The activation of protein kinase C mediated by high glucose in MDCK cells

Jiang Tao; et al

doi:10.13406/j.cnki.cyxb.1999.03.005

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The activation of protein kinase C mediated by high glucose in MDCK cells

更新时间：2024-01-17

- The activation of protein kinase C mediated by high glucose in MDCK cells
- Journal of Chongqing Medical University Issue 3, Pages: 236-238(1999)
- 作者机构：
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- DOI：10.13406/j.cnki.cyxb.1999.03.005
  CLC： R587.2
- Published：1999，
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[1]蒋涛,汪恕萍,周波,曾昭淳.高葡萄糖介导MDCK细胞蛋白激酶C活性变化[J].重庆医科大学学报,1999(03):236-238.

Jiang Tao, et al. The activation of protein kinase C mediated by high glucose in MDCK cells. [J]. Journal of Chongqing Medical University (3):236-238(1999)
[1]蒋涛,汪恕萍,周波,曾昭淳.高葡萄糖介导MDCK细胞蛋白激酶C活性变化[J].重庆医科大学学报,1999(03):236-238. DOI： 10.13406/j.cnki.cyxb.1999.03.005.

Jiang Tao, et al. The activation of protein kinase C mediated by high glucose in MDCK cells. [J]. Journal of Chongqing Medical University (3):236-238(1999) DOI： 10.13406/j.cnki.cyxb.1999.03.005.

摘要

观察了高葡萄糖对MDCK细胞蛋白激酶C（PKC）信号转导通路的影响。结果表明MDCK细胞在高葡萄糖环境下，PKC从细胞浆到细胞膜移位活化，同时细胞Na+，K+－ATP酶活性下降，此可为PKC抑制剂staurosporine所阻止。因此，高糖引起肾小管细胞PKC信号系统异常可能是糖尿病肾病发生的重要机制。

Abstract

The effect of high glucose on the signal transduction pathway of protein kinase C (PKC) in MDCK cells wasobserved. It was found that PKC was activated via trans1ocation from cytosol to membrane in cultured MDCKce1ls exposed to high dextrose. However

the activity of Na+

K+-ATPase was decreased and tliis can beprevented by PKC inhibitor staurosporine(SS). These findings suggested that the activation of PKC signaltransduction pathway induced by elevated glucose in renal tubular epithelial cells may be involved in thepathogenesis of diabetic nephropathy.

关键词

蛋白激酶CNa+，K+－ATP酶糖尿病肾病

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Related Author

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et al

蒋涛

曾昭淳

ZHANG Zhicheng

陈伟

何瑛

Li Li

Related Institution

Department of Endocrinology,College of Clinical Medicine,Chongqing Medical University

重庆医科大学基础医学院生化教研室

Department of Clinical Liaboratory,Daping Hospital, the Third Military Medical University

第三军医大学大坪医院检验科

Department of Endocrinology，the Zhongshan Hospital of Chongqing

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