Nitric oxide and lung cancer immunity

doi:10.13406/j.cnki.cyxb.1998.04.031

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Nitric oxide and lung cancer immunity

更新时间：2024-01-17

- Nitric oxide and lung cancer immunity
- Journal of Chongqing Medical University Issue 4, Pages: 338-341(1998)
- 作者机构：
  
  1. 重庆医科大学第二临床学院肺科
  2. 重庆医科大学临床学院肺科
  3. 重庆医科大学临床学院肺科主治医师
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1998.04.031
  CLC： R734.2
- Published：1998，
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[1]李升锦,张和生,张治,邓峰,张朝丽.一氧化氮与肺癌免疫的研究[J].重庆医科大学学报,1998(04):338-341.

Nitric oxide and lung cancer immunity. [J]. Journal of Chongqing Medical University (4):338-341(1998)
[1]李升锦,张和生,张治,邓峰,张朝丽.一氧化氮与肺癌免疫的研究[J].重庆医科大学学报,1998(04):338-341. DOI： 10.13406/j.cnki.cyxb.1998.04.031.

Nitric oxide and lung cancer immunity. [J]. Journal of Chongqing Medical University (4):338-341(1998) DOI： 10.13406/j.cnki.cyxb.1998.04.031.

摘要

采用镀铜镉还原法检测肺癌、良性肺病和肺部正常者血清及支气管冲洗液（BWF）中一氧化氮（NO）水平

并对 BWF 中 NO 与 T 淋巴细胞亚群的相关性进行了分析。结果显示

肺癌组 BWF 中 NO 水平明显高于良性肺病组及正常癌组（P

0.01）

但肺癌组血清 NO 水平与良性肺病组比较无差别（P

0.1）;肺癌组 BWF 与血清 NO 水平之间呈正相关（P

0.01）:Ⅲ、Ⅳ期肺癌血清 NO 明显高于Ⅰ、Ⅱ期肺癌和良性肺病组（P

0.01）;NO 水平与肺癌组织学类型无关。BWF 中 NO 水平与 CD

/CD

比值呈明显负相关（r=-0.67

0.01）.以上结果提示在肺癌免疫研究中

NO 水平的增加可能主要起局部免疫抑制作用。

Abstract

The levels of nitric oxide（NO）synthesis were measured by a copper-coated cadmium reduction method in human serum and bronchial washing fluid（BWF）from 25 patients with Lung cancer（LC）

14 patients with benign pulmonary disease（BPD）and 18 normal controls（NC）

along with the correlation between NO and Tlymphocyte subpopulation in BWF.Results:Serum NO level in patients with LC and BPD were significantly higher（P

0.01） than those in NC

but there were no significant difference（P

0.1）in patients with LC and BPD.The levels of BWF NO in patients with LC were significantly higher（P

0.01）than those in patients with BPD.The BWF levels of NO had postitive correlation with serum levels of it in LC patients（P

0.01）.No correlation could be found in BPD patients and NC

In TNM stages Ⅰ to Ⅳ of patients with LC

the levels of NO stages Ⅲ and Ⅳ were significantly higher（P

0.01）than those in the stages Ⅰ and Ⅱ and BPD.There were no differences in stages Ⅰ and Ⅱ and the NC

No correlation could be found in the levels of NO and the histologic type of the tumors.The study of the correlation between NO and T-lymphocyte subpopulation in BWF showed that the levels of NO had negative correlation with in CD

/CD

ratio（r=-0.67

0.01）.In immunity study of LC

high levels of NO may be involved in the local immunosuppression.The determination of NO levels in BWF may be a helpful method for monitoring the immunity status and also useful for differential diagnosis of LC.

关键词

一氧化氮肺癌免疫抑制

Keywords

nitric oxidelung cancerimmunosuppression

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