Heart rate variability and its circadian rhythm in unstable angina pectoris

doi:10.13406/j.cnki.cyxb.1998.04.007

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Heart rate variability and its circadian rhythm in unstable angina pectoris

更新时间：2024-01-17

- Heart rate variability and its circadian rhythm in unstable angina pectoris
- Journal of Chongqing Medical University Issue 4, Pages: 352-355(1998)
- 作者机构：
  
  1. 重庆医科大学临床学院内科
  2. 重庆医科大学临床学院内科住院医师
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1998.04.007
  CLC： R541.4
- Published：1998，
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[1]李骊华,赵万蓉,陈运贞.不稳定性绞痛心率变异性及其昼夜节律的定量研究[J].重庆医科大学学报,1998(04):352-355.

Heart rate variability and its circadian rhythm in unstable angina pectoris. [J]. Journal of Chongqing Medical University (4):352-355(1998)
[1]李骊华,赵万蓉,陈运贞.不稳定性绞痛心率变异性及其昼夜节律的定量研究[J].重庆医科大学学报,1998(04):352-355. DOI： 10.13406/j.cnki.cyxb.1998.04.007.

Heart rate variability and its circadian rhythm in unstable angina pectoris. [J]. Journal of Chongqing Medical University (4):352-355(1998) DOI： 10.13406/j.cnki.cyxb.1998.04.007.

摘要

本文用心率变异（HRV）频域和时域法对比研究不稳定性心绞痛（UAP）30例、稳定性心绞痛（SAP）22例及正常人20例的心脏自主神经活性及其昼夜节律。结果显示

UAP 组 HRV 频域和时域指标均明显减低（P

0.01）

且其昼夜变化明显减小。清晨 LF、HF、HF

迅速降低

、LF/HF 迅速升高（P

0.01）。UAP 重症患者变化更显著

治疗后各指标趋向正常。提示 UAP 患者心脏自主神经活性尤其迷走神经活性受损

致交感神经活性相对亢进;病情越重

受损越重;其节律仍有昼夜变化

但明显减小;清晨由迷走神经兴奋迅速转为交感神经兴奋

且呈相对亢进状态

可能起板机作用

导致急性心血管事件的高发。提出心脏自主神经活性异常或可作为冠心病病情判断的重要指标。

Abstract

The cardiac autonomic nervous activity（CANA）and its circadian rhythm were investigated by frenquency and time domain measures of heart rate variability（HRV）in 30 patients with unstable angina pectoris（UAP group）

22 with stable angina pectoris（SAP group）and 20 control subjects.The results showed that the index of HRV were all significantly lower（P

0.001）in UAP group and its circadian variation was markedly smaller compared with SAP and control groups.In the early morning

LF、HF、HF

decreased quickly with an sigificantly increase in LF

、LF/HF（P

0.01）.Patients in UAP subgroup with serious cihnical state had lower HRV than patients with mild symptoms

after treatment

HRV were partially restored.The study suggests that CANA are impaired especially vagal activity in UAP group

the sympathetic activity are relatively overactive.In serious UAP group

the CANA are impaired severely.In UAP group

CANA still have a ciradian rhythm

but less variation.In the early morning

the vagal hyperactivity transformed to sympathetic hyperactivity

which may trigger the peak occurence of acute cardiovascular events.Therefore

the abnormal CANA may be as a significant predictor of the patent’s clinical state.

关键词

不稳定性心绞痛心率功率谱分析心率变异性性自主神经活性性昼夜节律

Keywords

Unstable angina pectorisHeart rate power spectral analysisHeart rate variabilityAutonomic nervous activityCircadian rhythm

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