Analysis of causes of drug resistance and therapeutic effects on 35 multidrug resistant pulmonary tuberculosis patients

doi:10.13406/j.cnki.cyxb.1998.04.005

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Analysis of causes of drug resistance and therapeutic effects on 35 multidrug resistant pulmonary tuberculosis patients

更新时间：2024-01-17

- Analysis of causes of drug resistance and therapeutic effects on 35 multidrug resistant pulmonary tuberculosis patients
- Journal of Chongqing Medical University Issue 4, Pages: 413-415(1998)
- 作者机构：
  
  1. 重庆医科大学临床学院呼吸科
  2. 重庆市胸科医院主治医师
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1998.04.005
  CLC： R52
- Published：1998，
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[1]郭述良,罗永艾,黄习臣,吴亚梅,严晓峰.35例耐多药结核病临床成因分析与防治对策探讨[J].重庆医科大学学报,1998(04):413-415.

Analysis of causes of drug resistance and therapeutic effects on 35 multidrug resistant pulmonary tuberculosis patients. [J]. Journal of Chongqing Medical University (4):413-415(1998)
[1]郭述良,罗永艾,黄习臣,吴亚梅,严晓峰.35例耐多药结核病临床成因分析与防治对策探讨[J].重庆医科大学学报,1998(04):413-415. DOI： 10.13406/j.cnki.cyxb.1998.04.005.

Analysis of causes of drug resistance and therapeutic effects on 35 multidrug resistant pulmonary tuberculosis patients. [J]. Journal of Chongqing Medical University (4):413-415(1998) DOI： 10.13406/j.cnki.cyxb.1998.04.005.

摘要

据药敏试验观察复治肺结核患者中耐多药结核病（MDR-TB）发生率

循治疗传递进程分析MDR-TB 形成原因

并对符合诊断标准的35例 MDR-TB 患者重新制定方案督导治疗

观察疗效。结果 MDR-TB发生率为57.4%

只治不管、只治不教、治不规范、治不彻底等医源性因素是 MDR-TB 形成的主要原因。治疗9月后

35例患者中

11%死亡

28.6%痰菌转阴

52%X 线病灶显吸或吸收

说明 MDR-TB 治疗困难

死亡率高

应予高度重视。提高医生专业素质、归口管理、督导化疗、强化宣教是防止发生 MDR-TB 的关键。

Abstract

To find out the causes of multi-drug resistant tuberculosis(MDR-TB)

35 cases with MDR-TB were investigated according to an analysis of treatment delivery process

and then were treated with new regimens to evaluate the effects of retreatment.The results showed that irregular or improper treatment and short of health education and supervision of patients were the main reasons of MDR-TB formation

of 35 patients

4 died from complications of MDR-TB

10 sputum culture convert negtive and just 52% X-ray manifestations improved at end of 9 months treatment.These indicates it is difficult to cure MDR-TB.The best way to control MDR-TB is to prevent it by means of improving doctor’s acknowledge

of supervising on and educating TB patient in the course of treatment.

关键词

耐多药结核病肺流行病学药物治疗

Keywords

Tuberculosis PulmonaryTuberculosis Multi-drug Resistantepidemiologydrug therapy

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