Detection and significance of mycobacterial antigen and antibody in children CSF

Lu Xianyu Department of clinical microbiology

doi:10.13406/j.cnki.cyxb.1998.04.003

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Detection and significance of mycobacterial antigen and antibody in children CSF

更新时间：2024-01-17

- Detection and significance of mycobacterial antigen and antibody in children CSF
- Journal of Chongqing Medical University Issue 4, Pages: 373-375(1998)
- 作者机构：
  
  1. 重庆医科大学检验系临床微生物学教研室
  2. 儿童医院传染科
  3. 儿童医院传染科副教授
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1998.04.003
  CLC： R446.6
- Published：1998，
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[1]卢贤瑜,邓一平,陶昆,兰景刚,王绍映,胡修瑾.儿童脑脊液中结核菌抗原抗体检测及意义[J].重庆医科大学学报,1998(04):373-375.

Lu Xianyu Department of clinical microbiology. Detection and significance of mycobacterial antigen and antibody in children CSF. [J]. Journal of Chongqing Medical University (4):373-375(1998)
[1]卢贤瑜,邓一平,陶昆,兰景刚,王绍映,胡修瑾.儿童脑脊液中结核菌抗原抗体检测及意义[J].重庆医科大学学报,1998(04):373-375. DOI： 10.13406/j.cnki.cyxb.1998.04.003.

Lu Xianyu Department of clinical microbiology. Detection and significance of mycobacterial antigen and antibody in children CSF. [J]. Journal of Chongqing Medical University (4):373-375(1998) DOI： 10.13406/j.cnki.cyxb.1998.04.003.

摘要

为快速诊断结核性脑膜炎（简称结脑）

减少漏诊误诊

本文利用自制抗结核菌抗体

采用 ELISA 试验平行检测了24例结脑和29例其他疾病患儿脑脊液中结核菌抗原和抗 PPD 抗体 IgG。结果表明:检测抗原、抗体的敏感性分别为83.3%（20/24）

91.7%（22/24）;特异性分别为100%（29/29）

93.1%（27/29）。认为用 ELISA 法同时检测脑脊液中结核菌抗原和抗体比单检测抗原或抗体好

这样可以弥补单项检测的假阴性

减少漏诊

有助于快速诊断结脑。

Abstract

The mycobacterial antigen and IgG antibody to purified derivative(PPD)in cerebrospinal fluid of 24patients with tuberculous meningitis and 29 other patients were detected by means of Enzyme-linked immunosorbent assay(ELISA)in order to diagnose rapidly tuberculous meningitis(TBM).The sensitivity for the detection of antigen and antibody in CSF was 83.3 %(20/24)and 91.7%(22/24);and the specificity

100%(29/29)and 93.1%(27/29) Conclusion detecting simultaneously mycobacterial antigen and antibody in CSF is better than detecting only antigen or antiboby.It make up for false negative in the detection antigen alone or antibody alone and helps diagnose TBM rapidly.

关键词

结性脑膜炎酶联免疫吸附试验（ELISA）抗原抗体

Keywords

Tuberculous meningitis(TBM)Enzyme-linked immunosorbent assay (ELISA)Antigenantibody

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