An experimental model of delayed cerebral injury induced by subacute carbon monoxide intoxication in mice

doi:10.13406/j.cnki.cyxb.1998.04.002

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An experimental model of delayed cerebral injury induced by subacute carbon monoxide intoxication in mice

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- An experimental model of delayed cerebral injury induced by subacute carbon monoxide intoxication in mice
- Journal of Chongqing Medical University Issue 4, Pages: 332-335(1998)
- 作者机构：
  
  1. 重庆医科大学基础医学院药理教研室
  2. 重庆医科大学基础医学院药理教研室硕士生
  3. 重庆医科大学基础医学院药理教研室重庆医科大学基础医学院药理教研室硕士生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1998.04.002
  CLC： R-332
- Published：1998，
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[1]杨俊卿,周岐新.亚急性一氧化碳中毒致小鼠迟发性脑损伤模型的建立[J].重庆医科大学学报,1998(04):332-335.

An experimental model of delayed cerebral injury induced by subacute carbon monoxide intoxication in mice. [J]. Journal of Chongqing Medical University (4):332-335(1998)
[1]杨俊卿,周岐新.亚急性一氧化碳中毒致小鼠迟发性脑损伤模型的建立[J].重庆医科大学学报,1998(04):332-335. DOI： 10.13406/j.cnki.cyxb.1998.04.002.

An experimental model of delayed cerebral injury induced by subacute carbon monoxide intoxication in mice. [J]. Journal of Chongqing Medical University (4):332-335(1998) DOI： 10.13406/j.cnki.cyxb.1998.04.002.

摘要

本文报道了一种简便安全的亚急性一氧化碳（CO）中毒致迟发性学习记忆障碍的小鼠脑损伤模型。CO1ml/10g wt i.p

1/d

连续7天。跳台法被动性回避实验提示染毒小鼠出现学习损伤和记忆障碍;病理切片检查显示小鼠海马神经原细胞核固缩、细胞数目明显减少。结果表明本法具有定量可靠、方便

安全的优点。

Abstract

The experimental model of delayed cerebral damage was established in mice via CO 1ml/10g wt i.p

once a day

continuously 7 days.In the test of the passive avoidance task

we investigated the impairment of learning and memory function after CO exposure and the delayed neuronal death in hippocampus of mice.The model is simple

reliable

and safe

It perhaps becomes an effective model for us to illustrate the mechanism of delayed injury induced by CO.

关键词

亚急性 CO 中毒脑损伤学习记忆障碍模型

Keywords

COcerebral injurylearning and memorymodel

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