EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR

doi:10.13406/j.cnki.cyxb.1993.03.013

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EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR

更新时间：2024-01-17

- EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR
- Journal of Chongqing Medical University Issue 3, Pages: 206-210(1993)
- 作者机构：
  
  重庆医科大学基础核医学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1993.03.013
  CLC：
- Published：1993，
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[1]李少林,颜学先,王鼎年,王小青.五价锝标记的二巯基丁二酸应用于肝脏肿瘤显象的实验研究[J].重庆医科大学学报,1993(03):206-210.

EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR. [J]. Journal of Chongqing Medical University (3):206-210(1993)
[1]李少林,颜学先,王鼎年,王小青.五价锝标记的二巯基丁二酸应用于肝脏肿瘤显象的实验研究[J].重庆医科大学学报,1993(03):206-210. DOI： 10.13406/j.cnki.cyxb.1993.03.013.

EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR. [J]. Journal of Chongqing Medical University (3):206-210(1993) DOI： 10.13406/j.cnki.cyxb.1993.03.013.

摘要

国内外尚无将99mTe（V）—DMS应用于肝癌显象的报道。我们对其标记方法和条件加以改良

比较了在不同条件下得到的标记化合物在移植不同瘤种的小鼠体内的分布。结果证明可使瘤/肝比值提高至2.5～3.0左右。不仅适用于原发性肝癌也适用于肝内转移癌的显象。并进一步证明了pH在8.25～8.45之间时标记率最高。而且标记化合物的离解性在pH.45时最显著

根据Horiuch等的报道该化合物的离解性与其亲肿瘤性呈正相关

因而提示pH8.45时得到的标记化合物具有较好的亲肿瘤性。并且显象时间以2—4小时为最好。经重庆肿瘤研究所应用于55例肝癌病人的阳性显象

阳性率达88.5%

Abstract

To test bette’" tumor/liver ratio in tumor-bearing mice

the persant study was carried out in various conditions to clarify the applicability in the imaging of hepatic tumor. Various experimental condition.; wet’e tested by varying kinds of oxperimental tumor

concentration of the ligancl

time post-inject ion

and pM (8-9). And then we applied the 99mTc( V)-DMSA to the SPECT imaging of 35 patients with hepatic carcinoma

and of thisu

there were 88

5% true positives. The results of this study demonstrated that 99mTc; (V) -DMSA can be used as an effective imaging agent for hepatic cancer

关键词

二巯基丁二酸放射性核素显象肝脏肿瘤

Keywords

Dimercaptosuccinie acid Radionuclide imagingBiodistributipn

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