DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE

doi:10.13406/j.cnki.cyxb.1993.03.008

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DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE

更新时间：2024-01-17

- DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE
- Journal of Chongqing Medical University Issue 3, Pages: 194-198(1993)
- 作者机构：
  
  1. 重庆医科大学第二医院眼科
  2. 重庆医科大学第一医院临床药理研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1993.03.008
  CLC：
- Published：1993，
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[1]杨淑群,周远大,何海霞,李远宗,朱治本.诺氟沙星滴眼液点眼的眼内组织分布及其药代动力学研究[J].重庆医科大学学报,1993(03):194-198.

DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE. [J]. Journal of Chongqing Medical University (3):194-198(1993)
[1]杨淑群,周远大,何海霞,李远宗,朱治本.诺氟沙星滴眼液点眼的眼内组织分布及其药代动力学研究[J].重庆医科大学学报,1993(03):194-198. DOI： 10.13406/j.cnki.cyxb.1993.03.008.

DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE. [J]. Journal of Chongqing Medical University (3):194-198(1993) DOI： 10.13406/j.cnki.cyxb.1993.03.008.

摘要

对诺氟沙星滴眼液点眼后家兔眼组织中浓度用高效液相色谱法进行测定

推算眼内通透性和药代动力学。结果表明

诺氟沙星滴眼液点眼后迅速进入家兔眼内各组织

其中角膜的浓度最高

其次为虹膜-睫状体、晶体、玻璃体和房水。诺氟沙星滴眼液对角膜上皮的渗透性为2.91×10

-5

。各组织中药物消除半衰期分别为:泪液2.99h、角膜0.69h、房水1.82h、虹膜-睫状体1.18h、晶体1.23h、玻璃体0.51h。而各组织中的Cmax分别是:角膜9.18μg/g、房水0.35μg/ml;虹膜-睫状体5.17μg/g、晶体1.36μg/g、玻璃体0.59μg/ml

Abstract

The intraocular penetration and pharmacokinetio analysis of norfloxacin were dbserved.The concentration of norfloxacin was measured successflly by high performance liquid chromatography (HPLC) after topically applying 0.3% norfloxacin eyedrops to rabbit eyes. The results showed that norfloxacin could rapidly penetrate into rabbit ocular tissues. The concentration order was cornea

iris-ciliary body

lens

vitreous body

aqueous humour. Among all tissues concentration of norf loxacin in cornea was the highest. The permeability of norfloxacin in cornea epithelial barrier(Kep)was 2.91 10-’.The half-life ( Tl/2)of tha tissue concentration in lacritnal fluid

cornea

aqueous humour

iris-ciliary body

lens and vitreous body was 2.99h

0.69h

1.82h

1.18h

1.23h and O.Slh

respectively. The peak conc-entration(Cmax) of norfloxacin in the tissues was 9.18p.g/g in cornea

0.35ng/ml in aqueous humour

5.l7|ig/g in iris-ciliary body

1.36|ig/g in lens and 0.59ug/ml in vitreous. The experiment indicates that norfloxacin can maintain higher concentration in lacrimal fluid and cornea. Therefore

it is the first choice of drugs for treatment of superficial ocular infection

关键词

诺氟沙星滴眼液药代动力学高效液相色谱法

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