A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca<sup>2+</sup> CONCENTRATION OF THE HEPATOCYTES

doi:10.13406/j.cnki.cyxb.1993.03.004

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A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca²⁺ CONCENTRATION OF THE HEPATOCYTES

更新时间：2024-01-17

- A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca²⁺ CONCENTRATION OF THE HEPATOCYTES
- Journal of Chongqing Medical University Issue 3, Pages: 181-184(1993)
- 作者机构：
  
  重庆医科大学病理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1993.03.004
  CLC：
- Published：1993，
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[1]管小琴,苗德林,程本宽.肝细胞气球样变与细胞内Ca~(2+)浓度关系探讨[J].重庆医科大学学报,1993(03):181-184+250.

A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca²⁺ CONCENTRATION OF THE HEPATOCYTES. [J]. Journal of Chongqing Medical University (3):181-184(1993)
[1]管小琴,苗德林,程本宽.肝细胞气球样变与细胞内Ca~(2+)浓度关系探讨[J].重庆医科大学学报,1993(03):181-184+250. DOI： 10.13406/j.cnki.cyxb.1993.03.004.

A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca²⁺ CONCENTRATION OF THE HEPATOCYTES. [J]. Journal of Chongqing Medical University (3):181-184(1993) DOI： 10.13406/j.cnki.cyxb.1993.03.004.

摘要

肝细胞坏死是病毒性肝炎病变特点上一

但其坏死机理尚未阐明。为此

本文以气球样肝细胞为重点

用电镜、组化及电镜细胞化学等方法观察SAH、CAH、CPH及GalN致大鼠肝细胞损伤。结果显示气球样肝细胞主要表现为线粒体肿胀

内质网扩张

胞质局灶性溶解及质膜受损

伴相应酶活性下降

包括Na

-K

-ATP酶、G-6-P酶、SDH等。由于质膜损伤

-K

-ATP酶活性下降

可导致细胞内Ca

浓度增加

后者激活磷脂酶等

严重破坏膜结构

致使细胞死亡。本文用ARS染色证实了气球样细胞Ca

浓度增加

提示病毒性肝炎细胞坏死可能与Na

-K

-ATP酶活性下降

细胞内Ca

浓度增加有关

Abstract

In order to study the early pathological changes of cellular necrosis in viral hepatitis

the injured hopatocytss were examined by means of histochemif al and electronmicroscopieal techniques. The Samples were obtained from patients of SAH

CAH

CPH and from rats treated with D-GalN

The observation was focused on cellular balloon degeneration

the results showed the characteristics of mitochondr-ial swelling

endoplasmic reticulum dilatation

cytoplasmic focal lysis and plasm-alemmal lesion with decrease of related enzymatic activities

including N?-K+-ATPase

G-6-Pase

SDH

etc.The lesion of plasma membrane and decrease of Na+-K+-ATPase led to cellular swslling and rise of Ca2+ concentration in cytoplasm

The latter activated phospho-lipases which destroyed the membrane structures

aad finally brought about disintegration and death of cells

the increasing Cai+ concentration in balloon hcpatoc-ytes was confirmed by ARS staining.These results suggest that the mechanism of hepatocellular necrosis in viral hepatitis may be related to intracellular accumulation of calcium ions

关键词

病毒性肝炎钙离子气球样肝细胞

Keywords

viral hepatitisballoon degenerationcalcium

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Related Author

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Related Institution

Department of Pharmacy, The NHC Key Laboratory of Drug Addiction Medicine, The First Affiliated Hospital of Kunming Medical University

Department of Pathology, The NHC Key Laboratory of Drug Addiction Medicine, The First Affiliated Hospital of Kunming Medical University

Department of Infectious Diseases and Liver Diseases, The NHC Key Laboratory of Drug Addiction Medicine, The First Affiliated Hospital of Kunming Medical University

Institute of Medical Biology, Chinese Academy of Medical Sciences

Department of Laboratory Medicine,College of Clinical Medicine,Chon gqing Medical University

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A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca2+ CONCENTRATION OF THE HEPATOCYTES

DOI：10.13406/j.cnki.cyxb.1993.03.004

摘要

Abstract

关键词

Keywords

references

A STUDY ON THE RELATIONSHIP BETWEEN BALLOON DEGENERATION AND INTERCELLULAR Ca²⁺ CONCENTRATION OF THE HEPATOCYTES