CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS

doi:10.13406/j.cnki.cyxb.1993.01.004

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CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS

更新时间：2024-01-17

- CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS
- Journal of Chongqing Medical University Issue 1, Pages: 11-14(1993)
- 作者机构：
  
  1. 重庆医科大学第二医院心内科
  2. 重庆医科大学同位素科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1993.01.004
  CLC：
- Published：1993，
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[1]凌宗秀,殷跃辉,罗开良,李增高,李德旺,张万钟,陈太弟,庞久高.RAAS、ANF、ERPF和24小时尿钠在心力衰竭中的改变及相互关系[J].重庆医科大学学报,1993(01):11-14.

CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS. [J]. Journal of Chongqing Medical University (1):11-14(1993)
[1]凌宗秀,殷跃辉,罗开良,李增高,李德旺,张万钟,陈太弟,庞久高.RAAS、ANF、ERPF和24小时尿钠在心力衰竭中的改变及相互关系[J].重庆医科大学学报,1993(01):11-14. DOI： 10.13406/j.cnki.cyxb.1993.01.004.

CHANGES OF RENIN-ANGIOTENSIN-ALDOSTE RONE SYSTEM, ATRIAL NATRIURETIC FACTOR,EFFECTIVE RENAL PLASMA FLOW AND 24h URINE SODIUM IN PATIENTS WITH HEART FAILURE AND THEIR CORRELATIONS. [J]. Journal of Chongqing Medical University (1):11-14(1993) DOI： 10.13406/j.cnki.cyxb.1993.01.004.

摘要

用放免法测定110例心力衰竭（CHF）患者及35例正常人的肾素（PRA）、血管紧张素（A

Ⅰ

）、醛固酮（ALD）、心钠素（ANF）、有效肾血流量（ERPF）

部分人测定尿钠/24h。结果显示CHF时ERPF、尿钠/24h明显下降

PRA、A

Ⅰ

、ALD和ANF明显增高

并随心衰加重改变愈著

尤以肺心病最著。CHF时PRA、A

Ⅰ

、ALD呈正相关;PRA与ERPF负相关

与尿纳/24h不相关;ERPF、尿钠/24h与ALD不相关

与A

Ⅰ

负相关;ANF与ERPF负相关

与尿钠/24h、PRA、A

Ⅰ

和ALD不相关。提示CHF时上述神经体液因素失去正常规律

Abstract

Plasma renin activity (PRA)

angiotensin II (ANG II)

aldosterone (ALD)

atrial natriuretic factor (ANF) and effective renal plasma flow (ERPF) were measured with methods of radioimmunoassay in 110 patients with heart failure and in 35 normal controls

24th urine sodium significantly decreased and ANG II

ALD ANF apparently increased in patients with heart failurne

especially in those with cor pulmonale. The value of above determines was well correlated with the severity of heart failure

suggesting that they can be used as marks of heart failure severity.There was a possiuvive correlation among PRA

ANG II and ALD

and a negative correlation Ibetween PRA and ERPF

which consisted with pathophysiologic mechanisms of heart failure. Compared PRA with 24h urine sodium

ALD with ERPF

respectively

no correlations were demonstrated. Paro-doxically there was a negtive correlation between ANF anbd ERPF

ANG II with ERPF and 24h urine sodium

Tdese findings show that neurohumoral regulation is disturbed in heart failure

关键词

肾素血管紧张素醛固酮心钠素肾血流量充血性心力衰竭

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