ANTINEOPLASTIC DRUG SENSITIVITY TEST (MTT ASSAY) IN CHEMOTHERAPY OF GASTROINTESTINAL MALIGNANCY-A REPORT ON PRELIMINARY CLINICAL APPLICATION

doi:10.13406/j.cnki.cyxb.1992.04.008

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ANTINEOPLASTIC DRUG SENSITIVITY TEST (MTT ASSAY) IN CHEMOTHERAPY OF GASTROINTESTINAL MALIGNANCY-A REPORT ON PRELIMINARY CLINICAL APPLICATION

更新时间：2024-01-17

- ANTINEOPLASTIC DRUG SENSITIVITY TEST (MTT ASSAY) IN CHEMOTHERAPY OF GASTROINTESTINAL MALIGNANCY-A REPORT ON PRELIMINARY CLINICAL APPLICATION
- Journal of Chongqing Medical University Issue 4, Pages: 281-284(1992)
- 作者机构：
  
  1. 重庆医科大学第一医院普外科
  2. 重庆医科大学肿瘤病理生理研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1992.04.008
  CLC：
- Published：1992，
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[1]殷玉炳,罗崇德,韩文妙,郁解非,骆云鹏,汤为学,王瑞雪.抗癌药物敏感试验(MTT法)在胃肠道恶性肿瘤化疗中的临床应用[J].重庆医科大学学报,1992(04):281-284.

ANTINEOPLASTIC DRUG SENSITIVITY TEST (MTT ASSAY) IN CHEMOTHERAPY OF GASTROINTESTINAL MALIGNANCY-A REPORT ON PRELIMINARY CLINICAL APPLICATION. [J]. Journal of Chongqing Medical University (4):281-284(1992)
[1]殷玉炳,罗崇德,韩文妙,郁解非,骆云鹏,汤为学,王瑞雪.抗癌药物敏感试验(MTT法)在胃肠道恶性肿瘤化疗中的临床应用[J].重庆医科大学学报,1992(04):281-284. DOI： 10.13406/j.cnki.cyxb.1992.04.008.

ANTINEOPLASTIC DRUG SENSITIVITY TEST (MTT ASSAY) IN CHEMOTHERAPY OF GASTROINTESTINAL MALIGNANCY-A REPORT ON PRELIMINARY CLINICAL APPLICATION. [J]. Journal of Chongqing Medical University (4):281-284(1992) DOI： 10.13406/j.cnki.cyxb.1992.04.008.

摘要

作者采用抗癌药药敏试验（MTT法）

对33例胃肠道癌（25例结直肠癌

8例胃癌）进行6种抗癌药药物敏感性测定.结果表明:除4例因取样不足

组织培养不理想或培养污染外

检6成测功获者7.%;5-Fu、MMC在其余23例结直肠癌体外药敏试验中

显示敏感者分别为8.7%和21.7%;6例胃癌为16.7%和33.3%

该测试系统进一步证明

瘤细胞对抗癌药的反应存在着明显个体差异.本法有快速、简便、重复性好的优点

值得临床应用与推广

Abstract

Thirty-three cases of gastrointestinal cancers

25 colorectal and 8 gastric

were subjected to MTT assay using 6 antineoplastic drugs in vitro. Excluding 4 cases

2 colorectal and 2 gastric

in which the assay failed because of insufficient sampling

unsatisfactory tissue culture or contamination of the cultures

the assay succeeded in 87.9% of cases in this group. The sensitive rates for 5-fluorouracil and mitomy-cin C in colorectal cancers were 8.7% and 21.7% and those in gastric cancers were 16.7% and 33.3%. Further studies showed that there existed significant individual differences in the response of tumor cells to different drugs. We concluded that MTT assay had the advantages of quick and simple manipulation and easy to repeat

and it was suggested that it should be popularized clinically in the Treatment of malignancy

关键词

胃肠道癌抗癌药药敏试验MTT法化疗

Keywords

Gastrointestinal tumorAntineoplastic drug sensitivity testMTT assaychemotherapy

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EXPERIMENTAL STUDY ON MTT ASSAY USED I OR AlJNTICANCER DRUG SCREENNING

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