STUDIES ON C<sub>1</sub> ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE

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STUDIES ON C₁ ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE

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- STUDIES ON C₁ ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE
- Journal of Chongqing Medical University Issue 3, Pages: 172-175(1992)
- 作者机构：
  
  重庆医科大学药物化学及生物材料研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1992.03.002
  CLC：
- Published：1992，
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[1]余瑜,严桑和.异喹啉拉氏物烷基化反应的研究[J].重庆医科大学学报,1992(03):172-175.

Yu YuResearch Laboratory of Pharmaccutieal Chemistry and Biomalerials. STUDIES ON C₁ ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE. [J]. Journal of Chongqing Medical University (3):172-175(1992)
[1]余瑜,严桑和.异喹啉拉氏物烷基化反应的研究[J].重庆医科大学学报,1992(03):172-175. DOI： 10.13406/j.cnki.cyxb.1992.03.002.

Yu YuResearch Laboratory of Pharmaccutieal Chemistry and Biomalerials. STUDIES ON C₁ ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE. [J]. Journal of Chongqing Medical University (3):172-175(1992) DOI： 10.13406/j.cnki.cyxb.1992.03.002.

以碘代烷或氯化苄等高活性卤代烃与异喹啉拉氏物作用可使C

位烷基化制备得1-烷基异喹啉拉氏物.以溴环己烷作为烷化剂

则只能得到1-氰基异喹啉

产率达75%.为制备1-氰基异喹啉提供了一个新方法.

Reissert compound of isoquinoline can be alkylated by active alkylating agent

alkyl iodide or benzyl chloride according to Barrie’s method.A new compound

1-cyclohexyl Reissert compound

was prepared by using cyclohexyl iodide as alkylating agent.If cyclohexyl bromide was used as alkylating agent in the presence of sodium hydride

the product

instead of IIIc

was 1-cyanoisoquinoline (IV) with 75% yield.It may provide a new method of preparation of IV

but the necessity of the cyclohexyl bromide and the mechanism of the reaction remain for further investition

1-烷基异喹啉拉氏物1-氰基异喹啉1-环己基异喹啉拉氏物烷基化

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STUDIES ON C1 ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE