EVALUATION FOR FIVE INDICATORS FOR AGING

doi:10.13406/j.cnki.cyxb.1992.01.007

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EVALUATION FOR FIVE INDICATORS FOR AGING

更新时间：2024-01-17

- EVALUATION FOR FIVE INDICATORS FOR AGING
- Journal of Chongqing Medical University Issue 1, Pages: 31-34(1992)
- 作者机构：
  
  重庆医科大学检验系
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1992.01.007
  CLC：
- Published：1992，
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[1]王荣光,王霞文.五项衰老生化指标的探讨[J].重庆医科大学学报,1992(01):31-34.

EVALUATION FOR FIVE INDICATORS FOR AGING. [J]. Journal of Chongqing Medical University (1):31-34(1992)
[1]王荣光,王霞文.五项衰老生化指标的探讨[J].重庆医科大学学报,1992(01):31-34. DOI： 10.13406/j.cnki.cyxb.1992.01.007.

EVALUATION FOR FIVE INDICATORS FOR AGING. [J]. Journal of Chongqing Medical University (1):31-34(1992) DOI： 10.13406/j.cnki.cyxb.1992.01.007.

摘要

本文观察了2月、10月和24月龄大鼠红细胞膜Na

-K

-ATP酶、全血谷胱甘肽过氧化物酶（GSH-PX）

红细胞超氧化物歧化酶（SOD）活性及红细胞膜和血浆脂质过氧化物（LP0）水平

结果显示10月龄与2月龄组相比

-K

-ATP酶活性增高24.16%.GSH-PX活性增高4o.07%.红细胞膜LPO增高44.44%

血浆LPO增高了102.72%;24月龄与10月龄组相比

-K

-ATP酶活性下降45.16%

GSH-PX活性下降了22.3%

SOD活性下降12.32%

而红细胞膜LPO升高30.0%.由此认为上述5项指标可用于评估机体衰老情况

Abstract

The following indexes of 2

10 and 24 months old wistar rats were measured. the activities of RBC membrane Na+-K+-ATPase

RBC superoxide dismutasc (SOD)

blood glutathione. peroxidase (GSH-Px)

and the levels of lipid peroxides (EPO) in plasma and RBC membrane From 2 to 10 month-old animals

increases of 24.16%

40.07%

102.7% and 44.44%in Na-K-ATPase activity

GSH-Px activity

plasma LPO and RBC membra no LPO levels

respectively

were found (P<0.01). In 24 month-old rats

the activity of Na+-K+-ATPase

SOD and GSH-Px delined by 45.17%

12.32% and 22.39%

while the LPO level in RBC membrane rose by 30% (P<0.01). These results show that the 5 parameters change with aging

and can serve as biochemical indicators for aging

关键词

大鼠衰老超氧化物歧化酶谷胱甘肽过氧化物酶脂质过氧化物Na+-K+-ATP酶

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