EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT

doi:10.13406/j.cnki.cyxb.1991.04.013

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EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT

更新时间：2024-01-17

- EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT
- Journal of Chongqing Medical University Issue 4, Pages: 314-317(1991)
- 作者机构：
  
  重庆医科大学第一医院普外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.04.013
  CLC：
- Published：1991，
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[1]傅仲学,韩文妙.SOD促进大鼠结肠吻合口愈合的作用[J].重庆医科大学学报,1991(04):314-317.

EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT. [J]. Journal of Chongqing Medical University (4):314-317(1991)
[1]傅仲学,韩文妙.SOD促进大鼠结肠吻合口愈合的作用[J].重庆医科大学学报,1991(04):314-317. DOI： 10.13406/j.cnki.cyxb.1991.04.013.

EFFECT OF SOD ON THE HEALING OF COLONIC ANASTOMOSIS IN THE RAT. [J]. Journal of Chongqing Medical University (4):314-317(1991) DOI： 10.13406/j.cnki.cyxb.1991.04.013.

摘要

雄性Wistar大鼠124只随机分成对照组和SOD组

分别观察结肠吻合术后1、3、7天吻合口拉张强度、羟脯氨酸含量、组织学改变及血浆MDA含量

结果显示:SOD组吻合口抗张强度及羟脯氨酸含量均显著高于对照组（P<0.01或P<0.05）;术后1、3天SOD组血浆MDA含量显著低于对照组（P<0.05）;组织学显示SOD组较对照组炎症轻、胶原纤维束多、粘膜修复快.提示SOD有促进大鼠结肠吻合愈合口的作用

Abstract

One hundred and twenty-four male wistar rats were allocated rendomly to control and SOD group. The tensile strength

hydroxyproline contents and histologic changes of colonic anastomosis and MDA contents in plasma were observed on the 1st

3rd

7th day after surgery. The results show tensile strength and hydroxypr-oline contents in SOD group were much higher than that in control (P<0.01 or P <0.05). On the 1st. 3rd. day after surgery

MDA content of plasma in SOD groups was lower markedly than that in control (P<0.05). Histological observation show less inflamation and more bundle of collagen fibrils in SOD groups. The results indicate that the oxygen-derivod free radical may play an important role in affecting the healing of anastomosis

关键词

超氧自由基SOD结肠吻合伤口愈合

Keywords

Oxygen-derived free radicalSODColonic anastomosisWound healing

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