LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA

doi:10.13406/j.cnki.cyxb.1991.03.002

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LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA

更新时间：2024-01-17

- LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA
- Journal of Chongqing Medical University Issue 3, Pages: 180-184(1991)
- 作者机构：
  
  1. 重庆医科大学第一医院精神病学教研室
  2. 重庆医科大学中心实验室
  3. 重庆市第一精神病医院
  4. 重庆市第二精神病医院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.03.002
  CLC：
- Published：1991，
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[1]王克勤,张逢春,许炜,唐文淦,罗晓坡,段诚凤,王宪彬.碳酸锂治疗躁狂症时锂比值的探讨[J].重庆医科大学学报,1991(03):180-184.

LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA. [J]. Journal of Chongqing Medical University (3):180-184(1991)
[1]王克勤,张逢春,许炜,唐文淦,罗晓坡,段诚凤,王宪彬.碳酸锂治疗躁狂症时锂比值的探讨[J].重庆医科大学学报,1991(03):180-184. DOI： 10.13406/j.cnki.cyxb.1991.03.002.

LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA. [J]. Journal of Chongqing Medical University (3):180-184(1991) DOI： 10.13406/j.cnki.cyxb.1991.03.002.

摘要

39例躁狂症病人分别单用锂盐或合并氯丙嗪治疗

在血药浓度达到稳态时及继续治疗四周后

两次测定血浆锂、钠和钾浓度

红细胞锂及锂比值;其中合并用药组第二次抽血时氯丙嗪平均已停用17±8.5天.发现单用锂盐组大多数（约83%）在病情好转或缓解后锂比值升高合用氯丙嗪可使红细胞锂平均升高31%

锂比值升高20%.血浆锂与红细胞锂及锂比值相互呈正相关（r=0.713

0.885及0.929

P<0.001）.性别、家族史及血浆钠、钾水平与锂比值均无关

Abstract

This paper reports 39 cases of manic patients treated with lithium carbonate or lithium carbonate plus chlorpromazine. Levels of plasma lithium

sodium and potassium

erythrocyte lithium and lithium ratio -were determined when the blood lithium had reached the steady state and continued 4 weeks of treatment respectively. The mean duration of ditcontinuing chlorpromazine at the second time of determination in the combined drug group was 17±8.5 days.We found most lithium treated patients (83%) who got improvement or remission showed elevation of their lithium ratio. On the average

chlorpromazine can increase the erythrocyte lithium by 31 % and lithium ratio by 20%. Plasma lithium

erythrocyte lithium and lithium ratio were in positive correlation. Sex

family history

Plasma sodium and potassium level showed no correlation with their lithium ratio

关键词

躁狂症锂比值碳酸锂氯丙嗪

Keywords

ManiaLithium Ratiolithium carbonatechlorpromazine

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Related Author

Zhang Xuexue

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Related Institution

Graduate School of China Academy of Chinese Medical Sciences

Department of Psychiatric，the Fifth People’s Hospital in Nanning

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