ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS

Yang Feng et alDepartment of Physiology

doi:10.13406/j.cnki.cyxb.1991.03.001

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ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS

更新时间：2024-01-17

- ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS
- Journal of Chongqing Medical University Issue 3, Pages: 175-179(1991)
- 作者机构：
  
  重庆医科大学生理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.03.001
  CLC：
- Published：1991，
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[1]杨锋,周保和.大鼠尾壳核微量注射锂盐对痛反应的影响[J].重庆医科大学学报,1991(03):175-179.

Yang Feng et alDepartment of Physiology. ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS. [J]. Journal of Chongqing Medical University (3):175-179(1991)
[1]杨锋,周保和.大鼠尾壳核微量注射锂盐对痛反应的影响[J].重庆医科大学学报,1991(03):175-179. DOI： 10.13406/j.cnki.cyxb.1991.03.001.

Yang Feng et alDepartment of Physiology. ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS. [J]. Journal of Chongqing Medical University (3):175-179(1991) DOI： 10.13406/j.cnki.cyxb.1991.03.001.

摘要

本工作利用慢性埋置导管的方法将氯化锂直接注射于大鼠尾壳核头前区及头中心区

在核团水平分析锂盐影响动物痛阈的机制.结果表明:（1）尾壳核头前区注射锂盐可产生明显的镇痛作用

并可分别被纳洛酮、阿托品、酚妥拉明、心得安、荷包牡丹碱和二乙基麦角酰胺所对抗

但不能被氟哌啶醇所阻断.（2）尾壳核头中心区微量注射锂盐不能产生镇痛作用

Abstract

Effect of lithium salt(Li)administnation to caudate-putamen nucleus (CPN) on pain response in the rat was studied by chronic cannula implantation and direct injection of drugs into the brain structurementioned above. The results were as follows:( 1 ) The injection of Li into anterior part of the head of CPN of rats produced significantly the analgesic effect that could be antagonized by naloxone

atropine

phento-lamine.propranolol

lysergic acid diethylamide and bicuculline

but not by haloperidol.(2) The injection of Li into central part of the head of CPN of rats did not produce analgesic effect.The results above showed that microinjection of Li into different parts of the head of CPN could give rise to different effects on pain response and the analgesic effect of Li could be related to metabolic changes of endogenous opioid peptides

acetylcholine

noradrenaline

gama aminobutyric acid and 5-hydroXytryptamin aad mediated by their receptors respectively

关键词

氯化锂慢性埋置导管尾壳核纳洛酮阿托品酚妥拉明心得安二乙基麦角酰胺荷包牡丹碱氟哌啶醇

Keywords

LiChronic cannula implantationCaudate-putamen nucleusNalosoncAtropinePhentolaminePropranololLSDBicucullineHalopcridol

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