EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA

doi:10.13406/j.cnki.cyxb.1991.02.002

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EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA

更新时间：2024-01-17

- EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA
- Journal of Chongqing Medical University Issue 2, Pages: 96-101(1991)
- 作者机构：
  
  1. 重庆医科大学第二医院内科
  2. 重庆医科大学第二医院内科研究生
  3. 重庆医科大学第二医院内科重庆医科大学第二医院内科研究生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.02.002
  CLC：
- Published：1991，
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[1]左国庆,沈鼎明.血清岩藻糖化甲胎蛋白对原发性肝癌诊断价值的进一步探讨[J].重庆医科大学学报,1991(02):96-101.

EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA. [J]. Journal of Chongqing Medical University (2):96-101(1991)
[1]左国庆,沈鼎明.血清岩藻糖化甲胎蛋白对原发性肝癌诊断价值的进一步探讨[J].重庆医科大学学报,1991(02):96-101. DOI： 10.13406/j.cnki.cyxb.1991.02.002.

EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA. [J]. Journal of Chongqing Medical University (2):96-101(1991) DOI： 10.13406/j.cnki.cyxb.1991.02.002.

摘要

本文用小扁豆凝集素（LCA）亲和交叉免疫电泳法检测血清岩藻糖化甲胎蛋白（Fuc-AFP）共167例

结果进一步证明AFP岩藻糖化指数（Fucl）测定对原发性肝癌（PHC）（72例）诊断敏感性及特异性分别为84.7%和89.5%;在AFP阴性或低滴度阳性PHC病例中的阳性率达76.6%.FucI与AFP联合检测使诊断PHC的阳性率上升为90.3%.5例PHC手术切除或化疗后FucI随病情好转恶化而下降或上升.病理组织学检查结果提示PHC血清FucI的高低可能与肝癌细胞分化程度有关

Abstract

By means of crossed immuno-affinoelectrophresis

serum fucosylated AFP(Fuc AFP)was determined in 167 cases

including primary hepatic carcinoma (PHC) (72 cases)

various liver diseases(54 cases)

other gastrointestinal tumors (4 cases)

and healthy controls (37 cases) .The results showed that serum fucosylation index of AFP (FucI) was significantly higher in PHC than in controls and other diseases (P<0.001). As markers

FucI was useful in the diagnosis of PHC with sensitivity of 84.7% and specificity of 89.5%.The diagnostic positivity was 76.7% in PHC patients with normal or low producing AFP.Through combination of FucI and AFP assa-y

the diagnostic positivity was raised to 90.3%.Marked fall in both FucI and AFP levels were noted in 5 patients with PHC after surgical resection or chemotherapy. In correlation with Edmondson classification of 17 patients with hepatoma

it showed that the serum levels of FucI was higher in well differentiated tumors than in poorly differentiated ones

关键词

岩藻糖化甲胎蛋白原发性肝癌

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