SAS AND RAAS IN CIRRHOSIS: RELATIONSHIP TO RENAL FUNCTIONAL ABNORMALITIES

Zhao Qingxi & Xu Baoyuan Dept. of Int. The Second Hospital

doi:10.13406/j.cnki.cyxb.1991.01.001

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SAS AND RAAS IN CIRRHOSIS: RELATIONSHIP TO RENAL FUNCTIONAL ABNORMALITIES

更新时间：2024-01-17

- SAS AND RAAS IN CIRRHOSIS: RELATIONSHIP TO RENAL FUNCTIONAL ABNORMALITIES
- Journal of Chongqing Medical University Issue 1, Pages: 1-5(1991)
- 作者机构：
  
  重庆医科大学第二医院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1991.01.001
  CLC：
- Published：1991，
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[1]赵清喜,徐葆元.肝硬化患者SAS、RAAS与肾功能异常[J].重庆医科大学学报,1991(01):1-5.

Zhao Qingxi & Xu Baoyuan Dept. of Int. The Second Hospital. SAS AND RAAS IN CIRRHOSIS: RELATIONSHIP TO RENAL FUNCTIONAL ABNORMALITIES. [J]. Journal of Chongqing Medical University (1):1-5(1991)
[1]赵清喜,徐葆元.肝硬化患者SAS、RAAS与肾功能异常[J].重庆医科大学学报,1991(01):1-5. DOI： 10.13406/j.cnki.cyxb.1991.01.001.

Zhao Qingxi & Xu Baoyuan Dept. of Int. The Second Hospital. SAS AND RAAS IN CIRRHOSIS: RELATIONSHIP TO RENAL FUNCTIONAL ABNORMALITIES. [J]. Journal of Chongqing Medical University (1):1-5(1991) DOI： 10.13406/j.cnki.cyxb.1991.01.001.

摘要

本研究发现肝硬化腹水患者有效肾血浆流量及内生肌酐清除率显著降低

有明显的钠潴留;肝硬化时SAS及RAAS活动增强是肾脏钠潴留的重要因素.交感神经活动增强亦是肝硬化腹水患者肾血流动力学异常的重要原因之一

Abstract

The Sympathetic-adrenal system (SAS) and renin-angiotensin-aldosterone system (RAAS) in relation with the abnormalit-ies of renal function were studied in a total of 44 patients with liver cirrhosis and 35 cases of normal control. Our results showed that in patients with cirrhosis and ascites

a significant sodium retention was present

the renal blood flow and glomerular filtration rate were decreased; the plasma renin activity and the plasma concentrations of angiotensin II

aldosterone

nb-radrenaline

adrenaline and 24 hours urinary excretion of noradrenaline and adrenaline were all significantly increased

and they were negatively correlated with 24 hours urinary sodium excretion; a negative relationship also existed between plasma noradrenaline concentration and effctive renal plasma flow. It was concluded that the enhanced activities of RAAS and SAS were the important factors for renal sodium retention

and the latter was also playing an important role in the abnormality of renal hemo dynamics in patients with cirrhosis and ascites

关键词

交感肾上腺系统（SAS）肾素-血管紧张素-醛固酮系统（RAAS）肾血流动力学钠潴留肝硬化

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