DETERMINATIONS OF cAMP, cGMP AND CORTISOL LEVELS IN BLOOD AND cAMP AND cGMP LEVELS IN THE TISSUES OF THE INTERNAL ORGANS IN EXPERIMENTAL SEPTIC SHOCK

Wang Yong; et al

doi:10.13406/j.cnki.cyxb.1990.04.011

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DETERMINATIONS OF cAMP, cGMP AND CORTISOL LEVELS IN BLOOD AND cAMP AND cGMP LEVELS IN THE TISSUES OF THE INTERNAL ORGANS IN EXPERIMENTAL SEPTIC SHOCK

更新时间：2024-01-17

- DETERMINATIONS OF cAMP, cGMP AND CORTISOL LEVELS IN BLOOD AND cAMP AND cGMP LEVELS IN THE TISSUES OF THE INTERNAL ORGANS IN EXPERIMENTAL SEPTIC SHOCK
- Journal of Chongqing Medical University Issue 4, Pages: 288-291(1990)
- 作者机构：
  
  重庆医科大学儿科医院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1990.04.011
  CLC：
- Published：1990，
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[1]王勇,雷培芸,王赞尧,陈志远.内毒素休克过程中血浆和组织cAMP、cGMP含量及肾上腺功能变化的实验研究[J].重庆医科大学学报,1990(04):288-291.

Wang Yong, et al. DETERMINATIONS OF cAMP, cGMP AND CORTISOL LEVELS IN BLOOD AND cAMP AND cGMP LEVELS IN THE TISSUES OF THE INTERNAL ORGANS IN EXPERIMENTAL SEPTIC SHOCK. [J]. Journal of Chongqing Medical University (4):288-291(1990)
[1]王勇,雷培芸,王赞尧,陈志远.内毒素休克过程中血浆和组织cAMP、cGMP含量及肾上腺功能变化的实验研究[J].重庆医科大学学报,1990(04):288-291. DOI： 10.13406/j.cnki.cyxb.1990.04.011.

Wang Yong, et al. DETERMINATIONS OF cAMP, cGMP AND CORTISOL LEVELS IN BLOOD AND cAMP AND cGMP LEVELS IN THE TISSUES OF THE INTERNAL ORGANS IN EXPERIMENTAL SEPTIC SHOCK. [J]. Journal of Chongqing Medical University (4):288-291(1990) DOI： 10.13406/j.cnki.cyxb.1990.04.011.

摘要

用 44只大鼠在腹腔内注入活大肠杆菌复制内毒素休克动物模型。测定动物血浆oAMP和cGMP。取双肾上腺

左肾上极、左心室、肝右叶等处组织测cAMP、CGMP并同步测定血浆皮质醇。结果发现休克早期

肾上腺cAMP增高

血浆皮质醇亦增高;晚期

肾上腺cAMP、cGMP及血浆皮质醇均下降。作者认为在内毒素休克早期应用大量皮质醇可能是抗休克的有益措施

Abstract

Forty-four mice were used in this experiment. The animal model of septic shock was produced by intraabdomcnal injection of the viable B. coli. The animals were divided into 5 groups. During the course of the development of the septic shock.some of the animals were killed and blood from inferior vena cava was withdrawn for the determination of cAMP

cGMP and cortisol. Tissues from both sides of the adrenal glands

lower pole of the left kidney

left ventricle and right lobe of liver were removed for determination of cAMP and cGMP. The results showed that

during the early stagenof septic shock

the levels of cAMP

cGMP and cortisol were raised

followed by steady lowering of these levels as the shock became more profound.Base on the results of this experiment the author pointed out that the large dose glucocor-ticosteroids may be useful during the early stage of septic shock

关键词

环—磷酸腺苷环—磷酸鸟苷皮质醇中毒性休克

Keywords

cAMPcGMPCortisolSeptic shock

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Related Institution

Department of Endocrinology,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院内分泌科

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